Epidermal Growth Factor

Epidermal Growth Factor Basic information
Product Name:Epidermal Growth Factor
Synonyms:RECOMBINANT MOUSE EGF;RECOMBINANT HUMAN EGF;REC EPIDERMAL GROWTH FACTOR (HUMAN);REC EGF (HUMAN);RHEGF;MURINE URG;MURINE UROGASTRONE;MOUSE EGF
CAS:62253-63-8
MF:C270H401N73O83S7
MW:6221.96724
EINECS:810-845-4
Product Categories:Cytokine
Mol File:62253-63-8.mol
Epidermal Growth Factor Structure
Epidermal Growth Factor Chemical Properties
storage temp. -20°C
form powder
color white
Safety Information
WGK Germany 3
RTECS KB4518000
10-21
HS Code 2937190000
MSDS Information
ProviderLanguage
SigmaAldrich English
Epidermal Growth Factor Usage And Synthesis
DescriptionAn ophthalmic formulation of epidermal growth factor (urogastrone) has been launched for stimulation of healing of the corneal epithelium following various corneal diseases.
Chemical PropertiesEndotoxin < 0.1 ng per μg (1EU/ug) of EGF
OriginatorInpharzam (Italy)
UsesEpidermal Growth Factor, human, animal component free has been used:
  • as a supplement in in LHC-8 medium to culture liver cell lines
  • in the fetal bovine serum (FBS)-Dulbecco′s modified essential medium (DMEM) /F12 medium for primary culture of human glioma cells
  • as an additive in the conditional medium of normal fibroblasts (NFs) to study its effect on the migration and invasion of endometrial cancer (EC) cells
  • as a component in tumorsphere medium

UsesEGF (epidermal growth factor) human has been used in the culture medium for the maintenance of MCF10A cells (human mammary epithelial cells).
UsesThis product is used as a mitogen, triggering the cell to commence mitosis, in a variety of cell lines. In tissue cultures, EGF acts to reduce or eliminate the requirement for serum and can be used in conjunction with other media additives and hormones.
ApplicationEpidermal Growth Factor (EGF) is a human protein that is involved in the regulation of cell growth, differentiation and survival. Recombinant EGF is an antigen binding molecule that can be used as a cancer treatment. Recombinant EGF has been shown to stimulate cellular transformation by binding to the epidermal growth factor receptor. It also has been shown to inhibit the growth of breast cancer cells with the HER2 gene mutation. The molecular weight of rec EGF is approximately 25 kDa and is composed of 165 amino acids. Recombinant EGF can be used in immunoassays, as a model system for studying biological properties, or as an antibody production tool.
Brand nameGentel
General DescriptionEpidermal Growth Factor (EGF) is a small mitogenic polypeptide (~6 kDa), which is present in many mammalian species and is distributed throughout a wide number of tissues and body fluids.? Human EGF is identical to β-urogastrone, a polypeptide which was recognized and isolated on the basis of its ability to inhibit gastric acid secretion.? EGF is a member of a growth factor family, which is characterized by the presence of 6 conserved cysteine motifs that form three disulfide bonds. The location of 3 intrachain disulfide bonds in recombinant human EGF is identical to that of mouse EGF.? EGF is homologous to a sequence contained in a 19 kDa protein of vaccinia virus,? which appears to utilize the EGF receptor to gain entry into cell? EGF is mitogenic for a variety of epidermal and epithelial cells, including fibroblasts, glial cells, mammary epithelial cells, vascular and corneal endothelial cells, bovine granulosa, rabbit chondrocytes, HeLa cells, and SV40-3T3 cells.?
Biochem/physiol ActionsEpidermal growth factor (EGF) helps to induce cell growth, proliferation and differentiation. It participates in the repairing of renal tissues in the kidney. It promotes the reabsorption of magnesium with the help of the transient receptor potential cation channel 6 (TRMP6). EGF is known to participate in the pathophysiology of drug-induced renal magnesium loss.
Epidermal Growth Factor Preparation Products And Raw materials
EPIDERMAL GROWTH FACTOR, HUMAN Inositol Bovine FGF MONOCLONAL ANTI-EPIDERMAL GROWTH FACTOR ELISA-KINE PLUS? EPIDERMAL GROWTH FACTOR (3-[125I]IODOTYROSYL)EPIDERMAL GROWTH FACTOR, HUMAN,(3-[125I]IODOTYROSYL)EPIDERMAL GROWTH FACTOR, MOUSE,(3-[125I]IODOTYROSYL)EPIDERMAL GROWTH FACTOR, HUMAN OLIGOPEPTIDE RABBIT ANTI-EPIDERMAL GROWTH FACTOR EPIDERMAL GROWTH FACTOR POLYCLONAL ANTIBODY H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Epidermal Growth Factor EPIDERMAL GROWTH FACTOR RECEPTOR MONOCLONAL ANTIBODY TRP-HIS-TRP-LEU-GLN-LEU-LYS-PRO-GLY-GLN-PRO-MET-TYR EPIDERMAL GROWTH FACTOR RECEPTOR PEPTIDE (HUMAN),EPIDERMAL GROWTH FACTOR RECEPTOR PEPTIDE (985-996) (HUMAN),EPIDERMAL GROWTH FACTOR RECEPTOR PEPTIDE (985-996) REC EPIDERMAL GROWTH FACTOR (MOUSE) EPIDERMAL GROWTH FACTOR RECEPTOR FRAGMEN,epidermal growth factor receptor*fragment 661-681 EPIDERMAL GROWTH FACTOR RECEPTOR, ACTIVATED MONOCLONAL ANTIBODY EPIDERMAL GROWTH FACTOR, HUM Human Epidermal Growth Factor

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