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| | SPERMINE TETRAHYDROCHLORIDE Basic information |
| Product Name: | SPERMINE TETRAHYDROCHLORIDE | | Synonyms: | N,N'-BIS(3-AMINOPROPYL)-BUTANE-1,4-DIAMINE TETRAHYDROCHLORIDE;N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE 4 H CL;N,N'-BIS-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE TETRAHYDROCHLORIDE;N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TETRAHYDROCHLORIDE;NEURIDINE HYDROCHLORIDE;NEURIDINE TETRAHYDROCHLORIDE;MUSCULAMINE HYDROCHLORIDE;MUSCULAMINE TETRAHYDROCHLORIDE | | CAS: | 306-67-2 | | MF: | C10H30Cl4N4 | | MW: | 348.18 | | EINECS: | 206-189-8 | | Product Categories: | Glutamate receptor;Isolabel;co-factor | | Mol File: | 306-67-2.mol |  |
| | SPERMINE TETRAHYDROCHLORIDE Chemical Properties |
| Melting point | 310-311 °C (dec.)(lit.) | | density | 1.01 g/mL at 20 °C | | storage temp. | room temp | | solubility | H2O: 1 M at 20 °C, clear, colorless | | form | powder | | color | White to Almost white | | PH | 4.5-7.0 (25℃, 1M in H2O) | | Water Solubility | Soluble in water (348.2 g/L at 20°C). | | λmax | λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.15 | | BRN | 3911771 | | InChI | InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H | | InChIKey | XLDKUDAXZWHPFH-UHFFFAOYSA-N | | SMILES | C(CNCCCN)CCNCCCN.Cl.Cl.Cl.Cl | | CAS DataBase Reference | 306-67-2(CAS DataBase Reference) | | EPA Substance Registry System | Spermine tetrahydrochloride (306-67-2) |
| Hazard Codes | Xi | | Risk Statements | 36/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | EJ7230000 | | F | 3-10 | | TSCA | Yes | | HS Code | 29212900 |
| | SPERMINE TETRAHYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Uses | Spermine Tetrahydrochloride is an inhibitor of NOS1, NMDA, GluR, and PLCα. A useful reactant for Surface-?enhanced Raman spectroscopy (SERS) characterization of abasic sites in DNA duplexes. | | Uses | Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken. | | Uses | Used to precipitate DNA from low salt aqueous buffers. | | Biological Activity | Polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects. | | Biochem/physiol Actions | Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). | | storage | Desiccate at +4°C | | Purification Methods | Its pK values are similar to those of spermidine above. Purify it as for spermidine trihydrochloride above. [Beilstein 4 IV 1301.] |
| | SPERMINE TETRAHYDROCHLORIDE Preparation Products And Raw materials |
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