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| | SRT2104 (GSK2245840) Basic information |
| Product Name: | SRT2104 (GSK2245840) | | Synonyms: | SRT2104 (GSK2245840);(E)-3-(3-HYDROXY-4-METHOXYPHENYL)PROP-2-ENOIC ACID;GSK2245840;5-ThiazolecarboxaMide, 4-Methyl-N-[2-[3-(4-MorpholinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-2-(3-pyridinyl)-;sirtuin Modulator;4-Methyl-N-[2-[3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(pyridin-3-yl)thiazole-5-carboxamide;CS-2293;SRT-2104;SRT 2104 | | CAS: | 1093403-33-8 | | MF: | C26H24N6O2S2 | | MW: | 516.64 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1093403-33-8.mol |  |
| | SRT2104 (GSK2245840) Chemical Properties |
| density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in H2O; insoluble in EtOH; ≥6.46 mg/mL in DMSO with gentle warming | | form | Powder | | pka | 11.40±0.70(Predicted) |
| | SRT2104 (GSK2245840) Usage And Synthesis |
| Biological Activity | srt2104 (gsk2245840) is a selective sirt1 activator involved in the regulation of energy homeostasis. sirt1, also known as nad-dependent deacetylase sirtuin-1, is a member of the sirtuin family of proteins. | | in vitro | in c2c12 myoblasts stably transfected with small hairpin rna to knock-down sirt1, srt2104 increased ap activity, a marker for osteogenic differentiation. this effect was totally dependent on sirt1 expression [1]. | | in vivo | in male c57bl/6j mice, administration of srt2104 (100 mg/kg, p.o.) extended both mean and maximal lifespan of mice fed a standard diet, and enhanced bone mineral density, motor coordination, and insulin sensitivity and decreased inflammation. short-term srt2104 administration preserved bone and muscle mass in an experimental model of atrophy [1]. in male n171-82q hd mice with huntington's disease, srt2104 (diet containing 0.5% srt2104) effectively penetrated the blood-brain barrier, attenuated brain atrophy, improved motor function, and extended survival [2]. | | references | [1]. mercken e m, mitchell s j, martin‐montalvo a, et al. srt2104 extends survival of male mice on a standard diet and preserves bone and muscle mass[j]. aging cell, 2014, 13(5): 787-796.
[2]. jiang m, zheng j, peng q, et al. sirtuin 1 activator srt2104 protects huntington's disease mice[j]. annals of clinical and translational neurology, 2014, 1(12): 1047-1052. |
| | SRT2104 (GSK2245840) Preparation Products And Raw materials |
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