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| | 1-Bromo-2,4-difluorobenzene Basic information |
| Product Name: | 1-Bromo-2,4-difluorobenzene | | Synonyms: | 2,4-Difluoro-1-bromobenzene;1-BROMO-2,4-DIFLUOROBENZENE;Bromo-2,4-difluorobenzene;1-Bromo-2,4-difluorobenzene, 98+%;2,4-Difluoro;1-Bromo-2,4-difluorobenzene,min.98%;Benzene, 1-bromo-2,4-difluoro-;2,4-DIFLUOROBROMOBENZENE | | CAS: | 348-57-2 | | MF: | C6H3BrF2 | | MW: | 192.99 | | EINECS: | 206-479-4 | | Product Categories: | Aryl;C6;Aromatic Hydrocarbons (substituted) & Derivatives;Bromine Compounds;Fluorine Compounds;Halogenated Hydrocarbons;Other fluorin-contained compounds;Miscellaneous;bc0001 | | Mol File: | 348-57-2.mol |  |
| | 1-Bromo-2,4-difluorobenzene Chemical Properties |
| Melting point | -4 °C (lit.) | | Boiling point | 145-146 °C (lit.) | | density | 1.708 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.505(lit.) | | Fp | 125 °F | | storage temp. | Sealed in dry,2-8°C | | form | Liquid | | Specific Gravity | 1.708 | | color | Clear colorless to brown | | PH | 5.02 at 24℃ and 10g/L | | Water Solubility | INSOLUBLE | | BRN | 1680892 | | InChIKey | MGHBDQZXPCTTIH-UHFFFAOYSA-N | | CAS DataBase Reference | 348-57-2(CAS DataBase Reference) | | NIST Chemistry Reference | Benzene, 1-bromo-2,4-difluoro-(348-57-2) |
| | 1-Bromo-2,4-difluorobenzene Usage And Synthesis |
| Chemical Properties | Clear colorless to brown liqui | | Uses | 1-Bromo-2,4-difluorobenzene has been used in:
- preparation of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-sila-ethoxy)-propan-1-one
- enantiomeric preparation of the key intermediate of chiral azole antifungal agents by a chemoenzymatic process
| | General Description | 1-Bromo-2,4-difluorobenzene undergoes lithiation exclusively at the position having two adjacent halogen substituents, to yield 6-bromo-2,3-difluorobenzoic acid. |
| | 1-Bromo-2,4-difluorobenzene Preparation Products And Raw materials |
| Raw materials | Carbon tetrachloride-->1,3-Difluorobenzene-->(2,4-DIFLUOROPHENYL)TRIMETHYLSILANE-->Bromoacetonitrile | | Preparation Products | Fluconazole-->2,4-Difluorophenylboronic acid-->4-Bromo-3-fluorophenol-->2',4'-Difluoroacetophenone-->3-BROMO-2,6-DIFLUOROBENZALDEHYDE-->MK8245-->1-(5-Bromo-2,4-difluoro-phenyl)-ethanone-->3-bromo-2,6-difluorobenzoic acid-->(2R,3R)-2-(2,4-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol-->DIETHYL 2,4-DIFLUOROPHENYL MALONATE |
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