ChemicalBook Product Catalog Chemical Reagents Organic reagents Sulfonates / Sulfinates salts 2-Naphthalenesulfonyl chloride

2-Naphthalenesulfonyl chloride

2-Naphthalenesulfonyl chloride Basic information
Product Name:2-Naphthalenesulfonyl chloride
Synonyms:NAPHTHALENE-BETA-SULFONYL CHLORIDE;2-NAPHTHALENESULFONYL CHLORIDE;AKOS B022434;ART-CHEM-BB B022434;BETA-NAPHTHALENE SULFONYL CHLORIDE;2-Naphthalenylsulfonyl chloride;2-Naphthylsulfonyl chloride;beta-Naphthalenesulfochloride
CAS:93-11-8
MF:C10H7ClO2S
MW:226.68
EINECS:202-219-9
Product Categories:Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Indolines ,Indoles ,Indazoles;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Indazoles
Mol File:93-11-8.mol
2-Naphthalenesulfonyl chloride Structure
2-Naphthalenesulfonyl chloride Chemical Properties
Melting point 74-76 °C (lit.)
Boiling point 147.7 °C/0.6 mmHg (lit.)
density 1.3661 (estimate)
vapor pressure 0.004Pa at 25℃
Fp 200-202°C/13mm
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Toluene
form Powder
color Light yellow to beige
Water Solubility insoluble
Sensitive Moisture Sensitive
BRN 641898
InChIKeyOPECTNGATDYLSS-UHFFFAOYSA-N
LogP2.2 at 25℃
CAS DataBase Reference93-11-8(CAS DataBase Reference)
NIST Chemistry Reference2-Naphthalenesulfonyl chloride(93-11-8)
EPA Substance Registry System2-Naphthalenesulfonyl chloride (93-11-8)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-36/37/39-45-27
RIDADR UN 3261 8/PG 2
WGK Germany 3
F 21
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 29049020
MSDS Information
ProviderLanguage
2-Naphthalenesulfonyl chloride English
SigmaAldrich English
ACROS English
ALFA English
2-Naphthalenesulfonyl chloride Usage And Synthesis
Chemical PropertiesLIGHT YELLOW TO BEIGE POWDER
Uses2-Naphthalenesulfonyl chloride was employed as capping reagent for primary amine to convert histamine to a selective histamine H3-receptor antagonist. It was used for pre-column derivatization during the high-performance liquid chromatographic assay of neomycin sulfate.
Flammability and ExplosibilityNotclassified
Purification MethodsDistil the chloride in a vacuum and/or recrystallise it (twice) from *benzene/pet ether (1:1 v/v). Purify it as the 1-sulfonyl chloride above. [Fierz-Davaid & Weissenbach Helv Chim Acta 3 2312 1920.] The sulfonamide has m 217o (from EtOH). [Beilstein 11 III 399, 11 IV 529.]
2-Naphthalenesulfonyl chloride Preparation Products And Raw materials
Preparation ProductsNAPHTHALENE-2-SULFONAMIDE-->3-[(2-NAPHTHYLSULFONYL)AMINO]PROPANOIC ACID-->2-(NAPHTHALENE-2-SULFONYLAMINO)-BUTYRIC ACID-->Phenylalanine, N-(2-naphthalenylsulfonyl)--->(2-NAPHTHYLSULFONYL)AMINO]ACETIC ACID-->2-Naphthalenesulfonyl fluoride
6-CHLOROSULFONYL-2-HYDROXY-NAPHTHALENE-1-CARBOXYLIC ACID 7-Acetylamino-1-naphthalenesulfonyl chloride 2-ANTHRACENESULFONYL CHLORIDE 6-(P-TOLUIDINO)-2-NAPHTHALENESULFONYL CHLORIDE 6-DIAZO-5,6-DIHYDRO-5-OXO-1-NAPHTHALENESULFONYL CHLORIDE 9,10-Dibromoanthracene-2-sulfonyl Chloride 1-Tosyloxy-3-naphthalenesulfonyl chloride 2,7-NAPHTHALENEDISULFONYL CHLORIDE 4-[[4-(Dimethylamino)phenyl]azo]-1-naphthalenesulfonyl chloride 2,6-NAPHTHALENEDISULFONYL CHLORIDE 4-METHYL-1-NAPHTHALENESULFONYL CHLORIDE 7-CHLORO-NAPHTHALENE-2-SULFONYL CHLORIDE 6-(P-TOLUIDINO)NAPHTHALENE-2-SULFONYL 5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride 5-Chloronaphthalene-2-sulfonyl Chloride 6-DIAZO-5,6-DIHYDRO-5-OXO-1-NAPHTHALENESULFONYL CHLORIDE 2-DIMETHYLAMINONAPHTHALENE-6-SULFONYL CHLORIDE 2-Chloro-6-naphthalenesulfonyl chloride
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