Butyrophenone

Butyrophenone Basic information
Description References
Product Name:Butyrophenone
Synonyms:1-Butanone,1-phenyl-;1-phenyl-1-butanon;1-phenyl-butan-1-one;Butyrylbenzene;N-BUTANOPHENONE;N-BUTYROPHENONE;N-PROPYL PHENYL KETONE;PHENYL PROPYL KETONE
CAS:495-40-9
MF:C10H12O
MW:148.2
EINECS:207-799-7
Product Categories:Building Blocks;C10;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks;Pharmaceutical Intermediates;Aromatic Ketones (substituted);ketone
Mol File:495-40-9.mol
Butyrophenone Structure
Butyrophenone Chemical Properties
Melting point 11-13 °C(lit.)
Boiling point 228-230 °C(lit.)
density 1.021 g/mL at 25 °C(lit.)
refractive index n20/D 1.520(lit.)
Fp 192 °F
storage temp. Store below +30°C.
solubility Chloroform (Slightly), Methanol (Slightly)
form Liquid
Specific Gravity0.988
color Clear colorless to yellow
Odorat 100.00 %. camphor cherry walnut hazelnut
Odor Typecamphoreous
Water Solubility Insoluble in water.
BRN 508305
Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
LogP2.770
CAS DataBase Reference495-40-9(CAS DataBase Reference)
NIST Chemistry Reference1-Butanone, 1-phenyl-(495-40-9)
EPA Substance Registry System1-Butanone, 1-phenyl- (495-40-9)
Safety Information
Hazard Codes Xi
Risk Statements 41-43
Safety Statements 26-36/37/39-24/25-23
WGK Germany 3
TSCA Yes
HS Code 29143900
MSDS Information
ProviderLanguage
n-Butyrophenone English
SigmaAldrich English
ACROS English
ALFA English
Butyrophenone Usage And Synthesis
DescriptionButyrophenone is a chemical compound with the formula C10H12O. Butyrophenone has been used to study the relationship between the electrolyte counter-ion concentration and the critical micelle concentration for several surfactants. It has been used to generate PhCO+ ions by 70 eV electron ionization. Some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics. They can interfere with neurotransmitter functions, usually blocking dopamine receptors, and induce behavioral, endocrine, motor-kinetic effects. Examples of butyrophenones include: Haloperidol, the most widely used classical antipsychotic drug in this class; Benperidol, the most potent commonly used antipsychotic ( 200 times more potent than chlorpromazine).
References1. https://en.wikipedia.org/wiki/Butyrophenone
2. http://www.rightdiagnosis.com/medical/butyrophenone.htm
3. http://www.sigmaaldrich.com/catalog/product/aldrich/124338?lang=en&region=CA

Chemical Propertiescolourless to yellow liquid
UsesIntermediates of Liquid Crystals
UsesButyrophenone is used as intermediates of Liquid Crystals
Synthesis Reference(s)The Journal of Organic Chemistry, 61, p. 376, 1996 DOI: 10.1021/JO951500R
Tetrahedron Letters, 30, p. 6357, 1989 DOI: 10.1016/S0040-4039(01)93893-6
Biochem/physiol ActionsButyrophenones constitutes neuroleptic drugs and interacts with the opiate receptor by inhibiting the stereospecific binding of 3H-naloxone.
VITAMIN K1 Cyclopropyl phenyl ketone 5-Methoxy-3,4-dihydro-2H-naphthalen-1-one LAPACHOL 4'-Methylthio-γ-(1-pyrrolidinyl)butyrophenone 4'-Fluoro-γ-[(2-imidazolin-2-yl)amino]butyrophenone 4'-Fluoro-γ-[4-(o-hydroxyphenyl)-4-(hydroxymethyl)piperidino]butyrophenone 2,4-Dichlorobutyrophenone 4'-Fluoro-γ-(2-methyl-8-azaspiro[4.5]dec-8-yl)butyrophenone γ-(Dimethylamino)butyrophenone β-Methyl-4'-(piperidinocarbonylmethoxy)butyrophenone Benzoylcyclohexane 4'-Fluoro-γ-(4-hydroxy-4-phenylpiperidino)butyrophenone 4'-Fluoro-γ-[methyl[(1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-yl)methyl]amino]butyrophenone PHENYL VALERATE 2-ACETYL-1-TETRALONE 1-Phenyl-2-nitropropene 4-Phenylbutyrophenone

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