ChemicalBook Product Catalog Organic Chemistry Organometallic compounds Organomagnesium 4-FLUOROPHENYLMAGNESIUM BROMIDE

4-FLUOROPHENYLMAGNESIUM BROMIDE

4-FLUOROPHENYLMAGNESIUM BROMIDE Basic information
Product Name:4-FLUOROPHENYLMAGNESIUM BROMIDE
Synonyms:4-FLUOROPHENYLMAGNESIUM BROMIDE;4-FLUOROPHENYLMAGNESIUM BROMIDE, 2M IN DIETHYL ETHER;4-FLUOROPHENYLMAGNESIUM BROMIDE, 2.0M SO LUTION IN DIETHYL ETHER;4-FLUOROPHENYLMAGNESIUM BROMIDE SOL., ~2 .0 M IN DIETHYL ET;4-FLUOROPHENYLMAGNESIUM BROMIDE, 1.0M SO LUTION IN TETRAHYDROFURAN;4-FLUOROPHENYLMAGNESIUM BROMIDE SOL., ~1 M IN THF;4-Fluorophenylmagnesium Bromide 1.0 M In Tetrahydrofuran;4-Fluorophenylmagnesium Bromide 2.0 M In Diethyl Ether
CAS:352-13-6
MF:C6H4BrFMg
MW:199.3
EINECS:627-087-3
Product Categories:Grignard Reagents;Aryl;Organometallic Reagents;Grignard Reagent
Mol File:352-13-6.mol
4-FLUOROPHENYLMAGNESIUM BROMIDE Structure
4-FLUOROPHENYLMAGNESIUM BROMIDE Chemical Properties
Melting point 5 °C
Boiling point 66°C
density 1.043 g/mL at 25 °C
Fp −40 °F
storage temp. Flammables + water-Freezer (-20°C)e area
form Solution
color Clear yellow to red-brown
Water Solubility It reacts violently with water.
Sensitive Air & Moisture Sensitive
BRN 636802
InChIKeyQYBFFRXNNFXREA-UHFFFAOYSA-M
CAS DataBase Reference352-13-6
EPA Substance Registry SystemMagnesium, bromo(4-fluorophenyl)- (352-13-6)
Safety Information
Hazard Codes F+,C,F
Risk Statements 12-14-22-34-66-67-11-40-37-19
Safety Statements 16-26-36/37/39-43-45-7/8-33-8-7
RIDADR UN 2924 3/PG 2
WGK Germany 1
F 10-21
TSCA Yes
HazardClass 3
PackingGroup II
HS Code 29319090
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
4-FLUOROPHENYLMAGNESIUM BROMIDE Usage And Synthesis
Chemical Propertiesclear yellow to red-brown solution
Uses4-Fluorophenylmagnesium bromide is used as a reagent for the introduction of the 4-Fluorophenyl group.
Uses4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:
  • Useful key intermediate in the synthesis of paroxetine.
  • Arylsulfides via cross-coupling reaction with thiols.
  • 4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.
  • Grignard intermediate for preparing aprepitant.

4-FLUOROPHENYLMAGNESIUM BROMIDE Preparation Products And Raw materials
Preparation Products4-Fluorobenzeneboronic acid-->4-(4-FLUORO-PHENYL)-PIPERIDIN-4-OL HYDROCHLORIDE-->1-Fluoro-4-(1-methylethenyl)benzene-->2-(4-Fluorophenyl)-pyrrolidine-->4-Fluoro-1,1'-biphenyl-->BIS-(4-FLUORO-PHENYL)-PHENYL-METHANOL-->(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one
3-FLUOROPHENYLMAGNESIUM BROMIDE,3-FLUOROPHENYLMAGNESIUM BROMIDE, 0.5M SOLU TION IN TETRAHYDROFURAN,3-FLUOROPHENYLMAGNESIUM BROMIDE, 1.0M SO 3-chloro-5-fluorophenylmagnesium bromide solution,3-Chloro-5-fluorophenylmagnesium bromide 0.5M in THF,3-CHLORO-5-FLUOROPHENYLMAGNESIUM BROMIDE 4-FLUORO-1-NAPHTHYLMAGNESIUM BROMIDE 3-fluorophenylmagnesium bromide solution 3-CHLORO-4-FLUOROPHENYLMAGNESIUM BROMIDE 3-CHLORO-4-FLUOROPHENYLMAGNESIUM BROMIDE, 0.5M SOLUTION IN TETRAHYDROFURAN 4-FLUOROPHENYLMAGNESIUM BROMIDE 3,4-DIFLUOROPHENYLMAGNESIUM BROMIDE 3-chloro-4-fluorophenylmagnesium bromide solution 3-FLUOROPHENYLMAGNESIUM BROMIDE 1M SOLUTION IN THF 3 4 5-TRIFLUOROPHENYLMAGNESIUM BROMIDE 4-FLUORO-3-METHYLPHENYLMAGNESIUM BROMIDE 4-FLUORO-2-METHYLPHENYLMAGNESIUM BROMIDE PENTAFLUOROPHENYLMAGNESIUM BROMIDE 4-(1,3-DIOXAN-2-YL)-3-FLUOROPHENYLMAGNESIUM BROMIDE 3-(1,3-DIOXAN-2-YL)-4-FLUOROPHENYLMAGNESIUM BROMIDE Magnesium 4-CHLORO-3-FLUOROPHENYLMAGNESIUM BROMIDE
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