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ALPHA-AMANITIN

ALPHA-AMANITIN Basic information
Product Name:ALPHA-AMANITIN
Synonyms:Aids004473;Aids-004473;AMANITIN, a-(RG);AMANITIN, a-(RG)(CALL);cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4-8)-sulfide(R)-S-oxide;alpha-AMantine, froM AManita Phalloides;Α-AMANITIN;AMANITIN, A-
CAS:23109-05-9
MF:C39H54N10O14S
MW:918.98
EINECS:245-432-2
Product Categories:Alkaloids;DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience;Gene Regulation and Expression;Cell Signaling and Neuroscience;Mushroom;Toxins and Venoms;Enzyme Inhibitors;Enzyme Inhibitors by Type;Other;Miscellaneous Enzyme;inhibitor
Mol File:23109-05-9.mol
ALPHA-AMANITIN Structure
ALPHA-AMANITIN Chemical Properties
Melting point 254-255 °C(lit.)
alpha D20 +191°
Boiling point 1622.2±65.0 °C(Predicted)
density 1.1626 (rough estimate)
refractive index 1.7400 (estimate)
storage temp. −20°C
solubility H2O: 1.0 mg/mL
form powder
pka9.63±0.70(Predicted)
color white to light yellow
Water Solubility Soluble to 5 mM in ethanol and to 5 mM in water
Merck 13,370
BRN 1071138
Safety Information
Hazard Codes T+
Risk Statements 26/27/28-33-26/28
Safety Statements 36/37/39-45-36/37-28
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS BD6195000
F 8-10-18-21
HazardClass 6.1(a)
PackingGroup I
HS Code 2934999090
Hazardous Substances Data23109-05-9(Hazardous Substances Data)
ToxicityLD50 i.p. in albino mice: 0.1 mg/kg (Wieland, Wieland)
MSDS Information
ProviderLanguage
SigmaAldrich English
ALPHA-AMANITIN Usage And Synthesis
Usesα-Amanitin has been used:
  • for inducing transcriptional arrest in NT2 cells prior to immunofluorescence assay
  • to induce nephrotoxicity in mice renal tissues
  • to induce and analyse genotoxicity in mice bone marrow cells by cell viability assay, comet assay and chromosomal aberration assay

Biological Activityα-amanitin, the most deleterious toxin of a. phalloides to humans, inhibits rna polymerase ii (rnapii), causing hepatic and renal failure.
Biochem/physiol ActionsThe major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.
storageStore at -20°C
ALPHA-AMANITIN Preparation Products And Raw materials
gamma-amanitin alpha-Amanitin, 1-l-aspartic acid- ALPHA-AMANITIN OLEATE METHYL ALPHA-AMANITIN OLEATE ALPHA-AMANITIN 6'-O-methyl alpha-amanitin 4,9-dioxo-5,10-diazatetradecane
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