ChemicalBook Product Catalog Chemical Reagents Organic reagents Halogenated aliphatic hydrocarbons 3,5-Bis(trifluoromethyl)aniline

3,5-Bis(trifluoromethyl)aniline

3,5-Bis(trifluoromethyl)aniline Basic information
Product Name:3,5-Bis(trifluoromethyl)aniline
Synonyms:,,,’,’,’-Hexafluoro-3,5-xylidine;,5-Bis-trifluoromethyl-phenylamine;,5-Xylidine, a,a,a,a',a',a'-hexafluoro-;,a,a,a',a',a'-Hexafluoro-3,5-xylidine;3,5-bis(trifluoromethyl)-anilin;3,5-bis(trifluoromethyl)-benzenamin;3,5-Bis(trifluoromethyl)benzenamine;3,5-Di(trifluorometh
CAS:328-74-5
MF:C8H5F6N
MW:229.12
EINECS:206-335-0
Product Categories:Aniline series;Fluorobenzene;Anilines, Aromatic Amines and Nitro Compounds;Miscellaneous;Trifluoromethylbenzene serise
Mol File:328-74-5.mol
3,5-Bis(trifluoromethyl)aniline Structure
3,5-Bis(trifluoromethyl)aniline Chemical Properties
Melting point 168.2-169.2 °C
Boiling point 85 °C15 mm Hg(lit.)
density 1.467 g/mL at 25 °C(lit.)
refractive index n20/D 1.434(lit.)
Fp 182 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka2.15±0.10(Predicted)
form Liquid
Specific Gravity1.473
color Clear light yellow to yellow-brown
Water Solubility Not miscible in water.
BRN 654318
InChIKeyCDIDGWDGQGVCIB-UHFFFAOYSA-N
CAS DataBase Reference328-74-5(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenamine, 3,5-bis(trifluoromethyl)-(328-74-5)
EPA Substance Registry SystemBenzenamine, 3,5-bis(trifluoromethyl)- (328-74-5)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 33-36/37/38-20/21/22
Safety Statements 26-36/37/39-36
RIDADR 2810
WGK Germany 3
RTECS ZE9800000
Hazard Note Irritant
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29214910
MSDS Information
ProviderLanguage
3,5-Di(trifluoromethyl)aniline English
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3,5-Bis(trifluoromethyl)aniline Usage And Synthesis
Chemical Propertiesclear light yellow to yellow-brown liquid
Uses3,5-Bis(trifluoromethyl)aniline was found to be a highly efficient monodentate transient directing group (MonoTDG) for the palladium-catalyzed direct dehydrogenative cross-coupling of benzaldehydes with arenes.
SynthesisThe synthesis of 3,5-Bis(trifluoromethyl)aniline is as follows is as follows：Put 259g (1mol) 3,5-Bis(trifluoromethyl)nitrobenzeneand 500g ethyl acetate into a 1L autoclave, add 5g palladium-carbon as a catalyst, raise the temperature to 60℃, then pass the hydrogen pressure to 2MPa, keep the temperature and react for 20 hours, then cooling, filtration, concentration, and distillation to obtain 3,5-Bis(trifluoromethyl)aniline with a purity of 98.5% and a yield of 87%.
328-74-5.png
N1-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-((5-[(4,5-DICHLORO-1H-IMIDAZOL-1-YL)METHYL]-4-METHYL-4H-1,2,4-TRIAZOL-3-YL)THIO)ACETAMIDE 1,2-DI[3,5-DI(TRIFLUOROMETHYL)PHENYL]DIAZ-1-EN-1-IUM-1-OLATE 2-([3,5-DI(TRIFLUOROMETHYL)ANILINO]METHYLIDENE)-4,4,4-TRIFLUORO-1-(2-THIENYL)BUTANE-1,3-DIONE 3-((3,5-BIS(TRIFLUOROMETHYL)PHENYL)AMINO)-2-((2-CHLOROPHENYL)CARBONYL)PROP-2-ENENITRILE 2-CHLORO-1-(2-(2-[3,5-DI(TRIFLUOROMETHYL)ANILINO]ETHYL)PIPERIDINO)ETHAN-1-ONE N4-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-5-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE N1-(2,6-DIMETHYLPHENYL)-2,2-DICHLORO-2-[3,5-DI(TRIFLUOROMETHYL)ANILINO]ACETAMIDE 4-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-1-(2-THIENYLCARBONYL)THIOSEMICARBAZIDE N'3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-5-CHLORO-1-METHYL-1H-PYRAZOLE-3-CARBOHYDRAZIDE N1-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-CHLORO-2,2-DIFLUOROACETAMIDE N1-[2-(2-PIPERIDYL)ETHYL]-3,5-DI(TRIFLUOROMETHYL)ANILINE N3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-4,5,6,7-TETRAFLUORO-2-METHYLBENZO[B]FURAN-3-CARBOXAMIDE N-[2-(5-CHLORO-1,3-DIMETHYL-1H-PYRAZOL-4-YL)VINYL]-N'-[3,5-DI(TRIFLUOROMETHYL)PHENYL]UREA 3,5-BIS(TRIFLUOROMETHYL)ACETANILIDE 2-AMINO-4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]AMINO-1,3,5-TRIAZINE N1-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-BROMOPROPANAMIDE N-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)(3-(2-CHLOROPHENYL)-5-METHYLISOXAZOL-4-YL)FORMAMIDE 2-CHLORO(BIS-3',5'-TRIFLUOROMETHYLACETANILIDE)
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