magnolin

magnolin Basic information
Product Name:magnolin
Synonyms:1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl);Medioresinol dimethyl ether;tetrahydro-4-(3,4,5-trimethoxyphenyl)-,(1S,3aR,4S,6aR)-;Magnolin;Maglin;(1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyp...;(3S,3aR,6S,6aR)-3-(3,4-dimethoxyphenyl)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan;1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-, (1S,3aR,4S,6aR)-
CAS:31008-18-1
MF:C23H28O7
MW:416.46
EINECS:
Product Categories:Miscellaneous Natural Products
Mol File:31008-18-1.mol
magnolin Structure
magnolin Chemical Properties
Melting point 91.4-92.9 °C
Boiling point 536.9±50.0 °C(Predicted)
density 1.178±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
color White to Off-White
Safety Information
Safety Statements 24/25
HS Code 29329990
MSDS Information
magnolin Usage And Synthesis
DescriptionMagnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.
UsesMagnolin is a lignan extract from Magnoliae Flos, displaying anti-asthma and anti-inflammatory activity.
in vitroMagnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. Magnolin inhibits NF-κB transactivation activity by suppressing the ERKs/RSK2 signaling pathway. Magnolin inhibits the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) by inhibiting extracellular signal-regulated kinases (ERKs), which are key signaling molecules in the regulation of cell proliferation, transformation and cancer cell metastasis. JB6 Cl41 cell migration enhanced by EGF treatment is dramatically suppressed by Magnolin treatment in a dose-dependent manner. Magnolin inhibits ERK1/2/RSK2 signaling-mediated IκBα phosphorylation at Ser32, resulting in the inhibition of NF-κB activation and cell migration.
magnolin Preparation Products And Raw materials
(+)-MAGNOFLORINE IODIDE ARTEMISININ Taxifolin Verbascoside MAGNOFLORINE IODIDE, (+)-(RG) Ammothamnine Rhamnosylvitexin AURANTIO-OBTUSIN Nsc150443 FORSYTHIN FARGESIN Hydroxysafflor yellow A ENTERODIOL Terameprocol magnolin (+)-LARICIRESINOL SECOISOLARICIRESINOL (+)-PINORESINOL

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