Flutropium bromide

Flutropium bromide Basic information
Product Name:Flutropium bromide
Synonyms:[8-(2-Fluoroethyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2,2-diphenylacetate bromide;flutropium bromide;(endo,syn)-8-(2-Fluoroethyl)-3-[(hydroxyl-diphenylaeetyl)oxy]-8-methyl-8-azoniabicyclo[3.2.1]octane bromide;Flutropium;8-Azoniabicyclo[3.2.1]octane, 8-(2-fluoroethyl)-3-[(hydroxydiphenylacetyl)oxy]-8-methyl-, bromide, (3-endo,8-syn)-;8-Azoniabicyclo[3.2.1]octane, 8-(2-fluoroethyl)-3-[(hydroxydiphenylacetyl)oxy]-8-methyl-, bromide, (endo,syn)-;Ba 598Br;Flubron
CAS:63516-07-4
MF:C24H29BrFNO3
MW:478.39
EINECS:1533716-785-6
Product Categories:
Mol File:63516-07-4.mol
Flutropium bromide Structure
Flutropium bromide Chemical Properties
Melting point 192-193° (dec); mp 198-199° (dec)
Safety Information
ToxicityLD50 in male, female mice, male, female rats (mg/kg): 12.5, 11.0, 16.4, 18.4 i.v.; 760, 810, 830, 740 orally (Bauer, Fügner)
MSDS Information
Flutropium bromide Usage And Synthesis
DescriptionFlutropium bromide is an antitussive useful in the treatment of allergic rhinitis and in the symptomatic relief of bronchial asthma and chronic bronchitis. Recent studies suggest that flutropium bromide may have potential as a long-acting alternative to P-sympathomimetics or the xanthines in the prophylaxis of obstructive airways disease.
OriginatorBoehringer Ingelheim (W.Germany)
DefinitionChEBI: Flutropium bromide is the organic bromide salt of flutropium. It is used in Japan for the treatment asthma and chronic obstructive pulmonary disease. It has a role as a muscarinic antagonist, an antispasmodic drug and an anti-asthmatic drug. It contains a flutropium.
Brand nameFlubron
Flutropium bromide Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Dichloromethane-->Potassium permanganate-->Tropine-->2,2-Diphenylacetic acid-->FLUOROETHANE
Tiotropium bromide Diphenylphosphine Diphenyltropine Methyl Homatropine Hydrobromide Benzilic acid Rocuronium bromide Bensulfuron methyl Flutropium bromide Parathion-methyl Pinaverium bromide Diphenylsilane Kresoxim-methyl Chlorodiphenylphosphine Benzyldodecyldimethylammonium bromide CHLOROPHOSPHONAZO III Ipratropium bromide monohydrate tert-Butylchlorodiphenylsilane

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