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| | 2-Iodopyridine Basic information |
| | 2-Iodopyridine Chemical Properties |
| Melting point | 118-120℃ | | Boiling point | 52 °C (lit.) | | density | 1.928 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.6320(lit.) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Solid | | pka | pK1:1.82(＋1) (25°C) | | color | Pale yellow | | Water Solubility | Slightly soluble in water. | | Sensitive | Light Sensitive | | InChIKey | CCZWSTFVHJPCEM-UHFFFAOYSA-N | | CAS DataBase Reference | 5029-67-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29333990 |
| | 2-Iodopyridine Usage And Synthesis |
| Chemical Properties | Light yellow liquid | | Uses | 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors. | | Uses | 2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors. | | Reactions | 2-Iodopyridine and 3-alkoxy-2-iodopyridines are oxidized by DMDO to give PyIO2 , which serve as oxidants for alcohols and sulfides.
In palladium-catalyzed aminocarbonylation of 2-iodopyridine, 3-iodopyridine and iodopyrazine were coupled with CO and various primary and secondary amines. The biologically relevant N-substituted nicotinamides and 3-pyridyl-glyoxylamides were obtained from 3-iodopyridine as a result of simple and double carbon monoxide insertions, respectively. The chemoselectivity towards the ketoamide can be increased by the elevation of CO pressure. On the other hand, N-alkyl and N-aryl-carboxamides were obtained exclusively from CO pressure of 1 to 90 bar by using 2-iodopyridine and iodopyrazine.
Pd-catalyzed aminocarbonylation of 2-iodopyridine and 3-iodopyridine with primary and secondary amines. | | Synthesis Reference(s) | Tetrahedron Letters, 31, p. 6757, 1990 DOI: 10.1016/S0040-4039(00)97163-6 | | General Description | 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane. |
| | 2-Iodopyridine Preparation Products And Raw materials |
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