TRIOLEIN

TRIOLEIN Basic information
Biochemical Application Industrial Uses Applications in cosmetics
Product Name:TRIOLEIN
Synonyms:18:1TG;1,2,3-Propanetriyltri-((E)-9-octadecenoate);1,2,3-propanetriyltrioleate;9-Octadecenoic acid (Z)-, 1,2,3-propanetriyl ester;9-Octadecenoic acid 1,2,3-propanetriyl ester;9-Octadecenoicacid(Z)-,1,2,3-propanetriylester;9-octadecenoicacid(z)1,2,3-propanetriyl;9-octadecenoicacid(z)1,2,3-propanetriylester
CAS:122-32-7
MF:C57H104O6
MW:885.43
EINECS:204-534-7
Product Categories:chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:122-32-7.mol
TRIOLEIN Structure
TRIOLEIN Chemical Properties
Melting point -5,5°C
Boiling point 235-240 °C18 mm Hg(lit.)
density 0.91 g/mL(lit.)
refractive index n20/D 1.470
Fp 330 °C
storage temp. -20°C
solubility chloroform: 0.1 g/mL, clear, colorless
form Liquid
color Clear Pale Yellow
Merck 14,9732
BRN 1718692
Stability:Stability Stable, but air and light sensitive. Incompatible with strong oxidizing agents.
LogP23.444 (est)
CAS DataBase Reference122-32-7(CAS DataBase Reference)
EPA Substance Registry System9-Octadecenoic acid (9Z)-, 1,1',1''-(1,2,3-propanetriyl) ester (122-32-7)
Safety Information
Hazard Codes F,Xn
Risk Statements 11-20/21/22-53
Safety Statements 24/25-39-26
RIDADR UN 1282 3/PG 2
WGK Germany -
RTECS RG1936500
10-23
TSCA Yes
HS Code 29161500
Hazardous Substances Data122-32-7(Hazardous Substances Data)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
TRIOLEIN Usage And Synthesis
Biochemical Application

Glyceryl trioleate is derived from glycerol. It is composed of three oleic acid units and is an unsaturated triglyceride. Glyceryl trioleate has been used as an experimental diet along with fat-free basal mix and corn oil and then to access the dietary fat absorption among mice, as an interfering substance to test its effect on human serum in the approach to develop rapid enzyme immunoassay for the detection of retinol-binding protein, and as a standard in the determination of triglyceride concentration, colorimetrically using liver tissue sample from cows, and so on.

Industrial Uses

Triolein can be used as a textile finishing agent in textile industry, also used as additive in pigment grind. In pharm industry, it is used as an ointment, emulsifiable paste, suppository, lotion, emulsifier in air agent, stabilizing agent, lubricating agent, antifoaming agents. In food industry, it has the function as emulsify, disperse, defoaming, blister, antistaling of starch and control fat agglutination, usually used as an agent in candy, ice cream, cookie and bread. When triolein is used in beverage, could avoid ester to float, and avoid protein to sink, therefore to improve stability. When used in bread, cookie, could improve organization structure, increase volume, antistaling, prolongs warranty validity.

Applications in cosmetics
Triolen is widely used as the ingredients in cosmetics. Triolein has oleic acid in its structure, which is very beneficial for the skin. It is a skin-conditioning agent because it moisturizes the skin and forms a film over the skin. It can be used as a viscosity controlling agent, helps provide the desirable viscosity for a product, so it is used in body care, skin care and hair care products, toiletries, makeup products, and decorative cosmetics.
The Cosmetic Ingredient Review (CIR) Expert Panel found that dermal application of triolein was not associated with significant irritation, and no evidence of sensitization or photosensitization was observed. Ocular exposures were found to be only mildly irritating to eyes. Triolein has not been found to be genotoxic in a number of in vitro and in vitro assay systems. 
Description1,2,3-Trioleoyl glycerol is a triacylglycerol that contains oleic acid (Item Nos. 90260 | 24659) at the sn-1, sn-2, and sn-3 positions. It inhibits oxidized LDL-induced decreases in cell viability and superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities and increases in apoptosis in endothelial cells when used at a concentration of 10 μM. 1,2,3-Trioleoyl glycerol has been found in sunflower, corn, and extra virgin olive oils. It has been used as a standard for the quantification of triacylglycerols in extra virgin olive oil by high temperature gas chromatography-(ionic trap)mass spectrometry (HTGC-(IT)MS). 1,2,3-Trioleoyl glycerol is a major component of Lorenzo''s oil.
Chemical Propertiescolourless viscous liquid
Chemical PropertiesTriolein occurs as a clear, colorless to yellowish oily liquid, and is tasteless and odorless.
UsesGlycerol trioleate can be used as an emulsifier, also as creams, lotions and lipsticks matrix. Used as textile finishing agent in textile industry, also used as additive in pigment grind. In pharm industry, used as ointment, emulsifiable paste, suppository, lotion, emulsifier in air agent, stabilizing agent, lubricating agent, antifoaming agents. In food industry, it has the function as emulsify, disperse, defoaming, blister, antistaling of starch and control fat agglutination, usually used as agent in candy, ice cream, cookie and bread. When used in beverage, could avoid ester to float, and avoid protein to sink, therefore to improve stability. When used in bread, cookie , could improve organization structure, increase volume, antistaling, prolong warranty validity.
UsesGlyceryl trioleate has been used:
  • as an experimental diet along with fat-free basal mix and corn oil and then to access the dietary fat absorption among mice
  • as an interfering substance to test its effect on human serum in the approach to develop rapid enzyme immunoassay for the detection of retinol-binding protein
  • as a standard in the determination of triglyceride concentration, colorimetrically using liver tissue sample from cows

DefinitionChEBI: A triglyceride formed by esterification of the three hydroxy groups of glycerol with oleic acid. Triolein is one of the two components of Lorenzo's oil.
Production MethodsTriolein is manufactured by the esterification of fractionated fatty acids, mainly oleic acid and glycerin.
General DescriptionGlyceryl trioleate is derived from glycerol. It is composed of three oleic acid units and is an unsaturated triglyceride.
Flammability and ExplosibilityNonflammable
Pharmaceutical ApplicationsTriolein is used as a solubilizer and solvent in injectable preparations. It has been used in marketed preparations of sustained-release injections of cytarabine and multivesicular liposomal injections of morphine sulfate. It has also been used in enteric coatings for oral preparations in combination with other enteric coating excipients to protect against degradation by pancreatic lipase.
Triolen is used in personal care products as a skin-conditioning and viscosity-controlling agent.
SafetyTriolein is used in injectable preparations, in enteric coatings for oral preparations, and in personal care products. Chronic exposure may cause nausea and vomiting, and higher exposures may cause unconsciousness.
The Cosmetic Ingredient Review (CIR) Expert Panel found that dermal application of triolein was not associated with significant irritation, and no evidence of sensitization or photosensitization was observed. Ocular exposures were found to be only mildly irritating to eyes. Triolein has not been found to be genotoxic in a number of in vitro and in vitro assay systems. Subcutaneous injections of triolein in rats showed no tumors at the injection site. The CIR Expert Panel also noted that metabolism data indicated that glyceryl triesters (including triolein) followed the same metabolic pathways as fats in food. They were split into monoglycerides, free fatty acids, and glycerol, all of which were absorbed into the intestinal mucosa and metabolized further. Therefore, oral exposure to these compounds was not found to be a concern.
A triolein-based amphotericin emulsion showed better safety with a higher LD50 in rats as compared with the conventional amphotericin deoxycholate.

storageTriolein is classified as a stable compound but is sensitive to air and light. It should be stored in tightly sealed containers in a dry area at 2–8℃. Thermal decomposition of triolein may lead to release of irritating gases and vapors such as carbon oxides. Exposure to air and moisture over prolonged periods should be avoided.
IncompatibilitiesTriolein is incompatible with strong oxidizing agents and spontaneously flammable products. Being a triglyceride ester, triolein can be hydrolyzed by strong acids, and particularly by strong bases. It is possible for primary amines to form an adduct across the olefinic double bonds (analogous to a Michael addition).
Regulatory StatusIncluded in the FDA Inactive Ingredients Database (liposomal suspension for epidural injections). Included in parenteral medicines (suspension for intrathecal injection) licensed in the UK.
Triolein is included in the CIR category as safe for use in cosmetics and personal care products. Its use as an indirect food additive has been approved by the FDA.
TRIOLEIN Preparation Products And Raw materials
Raw materialsOleic acid
Preparation ProductsBUTYL OLEATE-->STEARIC ACID HYDRAZIDE-->isobutyl oleate-->2-ethylhexyl oleate-->1-Nonanal-->isopentyl oleate
Triolein (-14,14,15,15,17,18-D6) TRIOLEIN, [9,10-3H(N)] D-glucitol hexaoleate PEG-15 GLYCERYL TRIOLEATE SUCROSE PENTAOLEATE Triolein-1,2,3,7,8,9,10-13C7 GLYCEROL TRIACETYLRICINOLEATE TRIOLEIN (CAS#: 122-32-7) 1X2ML GLYCERYL-13C3 TRIOLEATE (TRIOLEIN) 99 AT PEG-25 GLYCERYL TRIOLEATE TRIOLEIN, [GLYCEROL-1,2,3-3H] TRIOLEIN, [125I] Triolein (-1-13C) Triolein-carboxyl-13c399atom%13c,triolein-carboxyls-13c3,TRIOLEIN-CARBOXYL-13C3,TRIOLEIN (1,1,1-13C3) Triolein-9,10-13C2 TRIOLEIN-GLYCERYL-13C3 TRIOLEIN, [CARBOXYL-14C] TRIOLEIN PEG-6 ESTERS Glycerol Trioleate Glyceryl Trioleate

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