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| | ISOGINKGETIN Basic information |
| Product Name: | ISOGINKGETIN | | Synonyms: | 2-(4-Methoxyphenyl)-5,7-dihydroxy-8-[2-methoxy-5-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one;2-(4-Methoxyphenyl)-8-[6-methoxy-3-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one;4',4'''-Dimethoxyamentoflavone;ISOGINKGETIN;Isoginkgetin, >99%;8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;3''',8-Biflavone, 5,5'',7,7''-tetrahydroxy-4',4'''-dimethoxy-;4',4'''-Dimethylamentoflavone | | CAS: | 548-19-6 | | MF: | C32H22O10 | | MW: | 566.51 | | EINECS: | | | Product Categories: | | | Mol File: | 548-19-6.mol |  |
| | ISOGINKGETIN Chemical Properties |
| Melting point | 355℃ | | Boiling point | 843.6±65.0 °C(Predicted) | | density | 1.506 | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml | | pka | 6.16±0.40(Predicted) | | form | powder | | color | White-beige | | LogP | 5.240 (est) |
| | ISOGINKGETIN Usage And Synthesis |
| Description | Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing. Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; ) and LPS by approximately 87 and 90%, respectively. It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; ) and the calcium ionophore A23187 by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM. Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner. | | Definition | ChEBI: A biflavonoid resulting from the formal oxidative dimerisation between position 8 of one molecule of 5,7-dihydroxy-4'-methoxyflavone and the 3' position of another. Found in the leaves of Ginkgo biloba, it is a potent inhibitor of matrix metal
oproteinase 9 (MMP-9). | | General Description | A cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax = 50 μM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 μM for 24 h). | | storage | Store at -20°C |
| | ISOGINKGETIN Preparation Products And Raw materials |
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