Suprofen

Suprofen Basic information
Product Name:Suprofen
Synonyms:Dolasetron Methanesulformte;MDL-73147EF:Anzemet;2-[4-(Thiophene-2-carbonyl)phenyl]propanoic acid;a-Methyl-p-(2-thenoyl)phenylacetic acid;2-[4-(thiophene-2-carbonyl)phenyl]propionic acid;1H-Indole-3-carboxylic acid(2α,6α,8α,9αβ)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester;Suprofen (200 mg);α-Methyl-4-(2-thienylcarbonyl)benzeneacetic Acid
CAS:40828-46-4
MF:C14H12O3S
MW:260.31
EINECS:255-096-9
Product Categories:Inhibitors;Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:40828-46-4.mol
Suprofen Structure
Suprofen Chemical Properties
Melting point 278°C
Boiling point 373.57°C (rough estimate)
density 1.2959 (rough estimate)
refractive index 1.5050 (estimate)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.5 mg/ml
pka3.91(at 25℃)
form Powder
Water Solubility soluble
CAS DataBase Reference40828-46-4(CAS DataBase Reference)
Safety Information
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III
HS Code 2934990002
ToxicityLD50 (7 days post-drug) in mice, rats, guinea pigs, dogs (mg/kg): 590, 353, 280, 160 orally (Niemegeers)
Suprofen Usage And Synthesis
DescriptionSuprofen is an arylpropionic acid analgesic/antiinflammatory agent with close structural resemblance to ketoprofen. It is more potent in many assays than indomethacin and ketoprofen and appears better tolerated.
Chemical PropertiesOff-White to Light-Brown
OriginatorJanssen (Belgium)
UsesProstaglandin biosynthesis inhibitor. Analgesic
UsesBridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
DefinitionChEBI: An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.
Brand nameProfenal (Alcon);Algiamida;Algiasdi;Bordol;Erdol;Masterfen;Sufenid;Supranol;Surfex;MALDOCIL.
Veterinary Drugs and TreatmentsSuprofen is a non-steroidal anti-inflammatory agent similar to flurbiprofen. Suprofen and flurbiprofen are phenylalkanoic acids that inhibit the cyclo-oxygenase enzymes responsible for conversion of arachadonic acid from cell membranes into various prostaglandins. These prostaglandins mediate certain aspects of ocular inflammation including disruption of the blood-aqueous barrier, uveal vasodilation, increases in intraocular pressure, and leakage of white blood cells and protein from uveal vessels into the aqueous humor. Prostaglandins cause iris sphincter constriction (miosis) independent of cholinergic mechanisms. Suprofen can inhibit this intraocular miosis and may also be useful in the management of uveal inflammation (usually in addition to topical steroids).
Flurbiprofen Cliprofen LC-R 505 suprofen acyl glucuronide Suprofen (S)-(+)-Suprofen,(S)-Suprofen Propionic acid 4-Methoxyphenylacetone SUPROFEN USP(CRM STANDARD) Thifensulfuron 4-((5-Bromo-2-thienyl)carbonyl)-alpha-methylbenzeneacetic acid suprofen-copper(II) complex (S)-(+)-2-Phenylpropionic acid Dearboxy suprofen Suprofen-D3 (R)-Suprofen,R(-)-Suprofen Tetrahydrothiophene Cephalothin sodium

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