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| | PROGUANIL HYDROCHLORIDE Basic information |
| Product Name: | PROGUANIL HYDROCHLORIDE | | Synonyms: | PROGUANIL HYDROCHLORIDE;(1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine;1-carbamimidoyl-1-(3,4-dichlorophenyl)-2-propan-2-yl-guanidine hydroch loride;N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide;N1-3,4-Dichlorophenyl-N5-isopropyldiguanide;Chloroproguanil;1-(3,4-Dichlorophenyl)-5-isopropylbiguanide;Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)- | | CAS: | 537-21-3 | | MF: | C11H15Cl2N5 | | MW: | 288.18 | | EINECS: | 208-660-3 | | Product Categories: | Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 537-21-3.mol |  |
| | PROGUANIL HYDROCHLORIDE Chemical Properties |
| Melting point | 120-121 °C | | Boiling point | 350.7±52.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 10.77±0.10(Predicted) | | form | Solid | | color | White to Off-White | | BCS Class | 1 | | Stability: | Hygroscopic |
| | PROGUANIL HYDROCHLORIDE Usage And Synthesis |
| Uses | PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).
| | Definition | ChEBI: Chlorproguanil is a dichlorobenzene. | | Clinical Use | Malaria chemoprophylaxis | | Drug interactions | Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with
artemether/lumefantrine; increased antifolate effect
with pyrimethamine. | | Metabolism | Proguanil is metabolised in the liver to the active
metabolite, cycloguanil, and to p-chlorophenylbiguanide
which is inactive, mainly by cytochrome P450, CYP
2C19 and slightly by CYP 3A4. Unlike proguanil and
p-chlorophenylbiguanide, cycloguanil is not concentrated
in erythrocytes so concentrations of cycloguanil in
plasma and whole blood are similar. About 40-60% of
a dose of proguanil is excreted in the urine, 60% of this
as the unchanged drug, 30% as cycloguanil, and 8% as
p-chlorophenylbiguanide. About 10% of a dose is excreted
in the faeces. |
| | PROGUANIL HYDROCHLORIDE Preparation Products And Raw materials |
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