ChemicalBook Product Catalog API Respiratory Drugs Antitussives CARBETAPENTANE CITRATE

CARBETAPENTANE CITRATE

CARBETAPENTANE CITRATE Basic information
Product Name:CARBETAPENTANE CITRATE
Synonyms:Atomin S;Gai-Less;CARBETAPENTANE CITRATE;CARBETAPENTANE CITRATE SALT;PENTOXIVERINE CITRATE;PENTOXYVERINE CITRATE;2-(2-(diethylamino)ethoxy)-ethano1-phenylcyclopentanecarboxylate(ester);Carbetapentane citrate/Pentoxyverine citrate
CAS:23142-01-0
MF:C26H39NO10
MW:525.59
EINECS:245-449-5
Product Categories:Respiratory system durgs;Intermediates & Fine Chemicals;Sigma receptor;Pharmaceuticals
Mol File:23142-01-0.mol
CARBETAPENTANE CITRATE Structure
CARBETAPENTANE CITRATE Chemical Properties
Melting point 84-86?C
storage temp. Sealed in dry,2-8°C
solubility H2O: soluble
form Solid
color White to Off-White
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS GY3500000
MSDS Information
ProviderLanguage
SigmaAldrich English
CARBETAPENTANE CITRATE Usage And Synthesis
Chemical PropertiesWhite to Off-White Solid
OriginatorAsthma ,Nichiiko
UsesSigma receptor agonist
Usesantibacterial, antiproliferative
UsesAn over-the-counter cough suppressant.
DefinitionChEBI: Carbetapentane citrate is a carbonyl compound.
Manufacturing Process1-Phenylcyclopentane carbonitrile was obtained by treatment of phenylacetonitrile with sodium amide and 1,4-dibrombutane.
1-Phenyl-1-cyclopentane carboxylic acid was produced in the result of reaction of 1-phenylcyclopentane carbonitrile with sulfuric acid.
1-Phenyl-1-cyclopentanecarbonyl chloride was obtained by treatment of 1phenyl-1-cyclopentane carboxylic acid with thionyl chloride.
A mixture of 0.5 mol of 1-phenyl-1-cyclopentanecarbonyl chloride and of 0.5 mol of 2-(2-diethylaminoethoxy)ethanol (herein-after referred to as the amino alcohol) in 300 ml of toluene is heated under reflux for 20 h. The mixture is thereafter made alkaline by means of an aqueous solution of caustic soda and decanted; the toluenic layer is washed with water and concentrated in vacuo. The residue is distilled under high vacuum. After two fractional distillations, the 2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentane-carboxylate is obtained, in 85% yield. Boiling point 164°C/0.1 mm. Hg.


Brand nameToclase (Pfizer).
Therapeutic FunctionAntitussive
Biological ActivityA selective ligand for the σ 1 -site.
CARBETAPENTANE CITRATE Preparation Products And Raw materials
Raw materialsSodium amide-->Thionyl chloride-->1,4-Dibromobutane-->6-Ethyl-3-oxa-6-azaoctanol
N,N-DIMETHYL(2-HYDROXYETHYL)AMMONIUM 2-HYDROXYACETATE ethyl cyclopentanecarboxylate 3-HYDROXY-3-METHYLGLUTARIC ACID 1-Phenylcyclopentanecarboxylic acid METHYL CYCLOPENTANECARBOXYLATE CARBETAPENTANE CITRATE Cetamiphen Minepentate ISOBUTYRIC ACID 2-ETHOXYETHYL ESTER ethyl 2-phenylbutyrate Ethyl 2,2-dimethylphenylacetate CYCLOPENTYLBENZENE 6-Ethyl-3-oxa-6-azaoctanol Cyclopentanecarboxylic acid 2-Phenyl-2-ethylbutyric acid CARBETAPENTANE TANNATE Butamirate citrate methyl 2-phenylbutyrate
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