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| | TRANS-ACONITIC ACID Basic information |
| Product Name: | TRANS-ACONITIC ACID | | Synonyms: | 1,2,3-PROPENETRICARBOXYLIC ACID;AKOS NCG1-0088;ACHILLEIC ACID;ACONITIC ACID, TRANS-;3-CARBOXY-PENT-2-ENEDIOIC ACID;(E)-1-PROPENE-1,2,3-TRICARBOXYLIC ACID;(E)-3-CARBOXY-PENT-2-ENEDIOIC ACID;PROPENE-TRANS-1,2,3-TRICARBOXYLIC ACID | | CAS: | 4023-65-8 | | MF: | C6H6O6 | | MW: | 174.11 | | EINECS: | 223-688-6 | | Product Categories: | antibiotic;monomer | | Mol File: | 4023-65-8.mol |  |
| | TRANS-ACONITIC ACID Chemical Properties |
| Melting point | 190 °C (dec.)(lit.) | | Boiling point | 225.05°C (rough estimate) | | density | 0.56 g/cm3 (20℃) | | FEMA | 2010 | ACONITIC ACID | | refractive index | 1.5860 (estimate) | | storage temp. | Store below +30°C. | | solubility | 400g/l | | pka | 2.8(at 25℃) | | form | Solid | | color | White to Off-White | | PH | 3.14(1 mM solution);2.48(10 mM solution);1.92(100 mM solution) | | Odor | at 100.00 %. vegetable musty nut dry toasted | | Odor Type | vegetable | | Water Solubility | Soluble in water at 20°C 400g/L. Slightly soluble in ether. | | BRN | 1725830 | | LogP | -0.14 | | CAS DataBase Reference | 4023-65-8(CAS DataBase Reference) | | EPA Substance Registry System | 1-Propene-1,2,3-tricarboxylic acid, (1E)- (4023-65-8) |
| | TRANS-ACONITIC ACID Usage And Synthesis |
| Chemical Properties | WHITE TO OFF-WHITE CRYSTALLINE POWDER | | Uses | It plays an important role as an antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes. trans-Aconitic acid is also used in synthesis of aconitate esters. It may be used for cross-linking polyvinyl alcohol film for preparing composite nanofiltration membranes. | | Definition | ChEBI: The trans-isomer of aconitic acid. | | General Description | trans-Aconitic acid is inhibitor of the tricarboxylic acid cycle and was identified in range grasses. | | Biochem/physiol Actions | Antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes. | | Purification Methods | Purify trans-acid by dissolving it in AcOH (77g/150mL), filtering and cooling. The acid separates (55g) as colourless needles. A further quantity (10g) can be obtained by reducing the volume of the filtrate. The acid is dried in air then in a vacuum desiccator over NaOH. The acid can be recrystallised from Me2CO/CHCl3. The highest melting point is obtained with the very dry acid. A melting point of 209o was obtained on a Dennis bar [Dennis & Shalton J Am Chem Soc 52 3128 1930, Bruce Org Synth Coll Vol II 12 1943]. [Beilstein 2 IV 2405.] |
| | TRANS-ACONITIC ACID Preparation Products And Raw materials |
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