ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Quinoline compounds 8-Methylquinoline

8-Methylquinoline

8-Methylquinoline Basic information
Product Name:8-Methylquinoline
Synonyms:8-Methylquinoline, 97% 5GR;8-Methylquinoline≥ 99% (GC);0-Toluquinoline;8-METHYLQUINOLINE;O-TOLUQUINOLINE;8-methyl-quinolin;8-Methylquinoline,98+%;8-Methyl
CAS:611-32-5
MF:C10H9N
MW:143.19
EINECS:210-264-0
Product Categories:API intermediates;Quinoline Derivertives;Alkylquinolines;Quinolines;Quinoline;Building Blocks;C8 to C10;Chemical Synthesis;Heterocyclic Building Blocks
Mol File:611-32-5.mol
8-Methylquinoline Structure
8-Methylquinoline Chemical Properties
Melting point -80 °C
Boiling point 245 °C
density 1.052 g/mL at 25 °C(lit.)
refractive index n20/D 1.614(lit.)
Fp 221 °F
storage temp. Room Temperature
solubility Chloroform, Methanol
pka5.03±0.17(Predicted)
form Liquid
color Clear yellow
Specific Gravity1.052
Water Solubility 0.1-0.5 g/100 mL at 17 ºC
BRN 111340
InChIKeyJRLTTZUODKEYDH-UHFFFAOYSA-N
CAS DataBase Reference611-32-5(CAS DataBase Reference)
NIST Chemistry ReferenceQuinoline, 8-methyl-(611-32-5)
EPA Substance Registry System8-Methylquinoline (611-32-5)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-68-22
Safety Statements 26-36-45-36/37/39
WGK Germany 3
RTECS VC0562000
TSCA T
HazardClass IRRITANT
HS Code 29334900
MSDS Information
ProviderLanguage
8-Methylquinoline English
SigmaAldrich English
ACROS English
ALFA English
8-Methylquinoline Usage And Synthesis
Chemical Propertiesclear yellow liquid
Uses8-Methylquinoline has been used in preparation of osmium chloridophosphine complexes, as quinoline carbene tautomers.Tumorigenic potential of 8-methylquinoline has been evaluated in newborn CD-1 mice and Sprague-Dawley rats.
Uses8-Methylquinoline is used in QSAR treatment of mutagenicity and cytotoxicity of quinolines.
DefinitionChEBI: A methylquinoline carrying a methyl substituent at position 8.
Synthesis Reference(s)The Journal of Organic Chemistry, 45, p. 1514, 1980 DOI: 10.1021/jo01296a035
General DescriptionYellow liquid or oil.
Air & Water ReactionsSlightly soluble in water.
Reactivity Profile8-Methylquinoline may be sensitive to exposure to light. May react vigorously with strong oxidizing agents and strong acids . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Fire Hazard8-Methylquinoline is combustible.
Purification MethodsPurify it as for 2-methylquinoline. The phosphate and picrate have m 158o and m 201o, respectively. [Beilstein 20 III/IV 3500, 20/7 V 405.]
Isoquinoline 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 8-Methylquinoline Quinclorac 8-ETHYL QUINOLINE 3-Quinolinecarboxylicacid,4-hydroxy-7,8-dimethyl-(9CI) Ethoxyquin 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 2,8-Dimethylquinoline 2,8-Bis(trifluoromethyl)-4-quinolinol 4-METHYLQUINOLINE 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ACID 8-Hydroxyquinoline 4,8-DIMETHYL-2-QUINOLINOL 5-7-DIMETHYL-1,2-BENZACRIDINE 8-acetylquinoline 6-Hydroxy-2(1H)-3,4-dihydroquinolinone Quinhydrone
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