BENORILATE

BENORILATE Basic information
Product Name:BENORILATE
Synonyms:2-acetoxy-4’-(acetamino)phenylbenzoate;4’-(acetamido)phenyl-2-acetoxybenzoate;aspirinacetaminophenester;benoral;benorilato;benortan;fenasparate;p-acetamidophenylacetylsalicylate
CAS:5003-48-5
MF:C17H15NO5
MW:313.3
EINECS:225-674-5
Product Categories:API
Mol File:5003-48-5.mol
BENORILATE Structure
BENORILATE Chemical Properties
Melting point 177-181℃
Boiling point 453.11°C (rough estimate)
density 1.2016 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka14.17±0.70(Predicted)
color White
Water Solubility 20mg/L(21 ºC)
Merck 14,1045
CAS DataBase Reference5003-48-5(CAS DataBase Reference)
Safety Information
RTECS VO0720000
HS Code 2924.29.7790
ToxicityLD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson)
MSDS Information
BENORILATE Usage And Synthesis
OriginatorBenortan,Winthrop,Switz.
UsesBenorilate is a codrug of Acetylsalicylic Acid (A187780) and Acetaminophen (A161220) and is used as an anti-inflammatory and antipyretic medication.
DefinitionChEBI: Benorilate is a carbonyl compound.
Manufacturing ProcessExample 1: 65 grams of N-acetyl-p-aminophenol were slurried with 400 ml of water and cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly added to the mixture with stirring, the temperature being maintained between 10°and 15°C. To the solution obtained, 75 grams of acetyl salicoyl chloride were added with vigorous stirring over a period of 1/2 hr, the solution being maintained at a temperature of about 10°C. Towards the end of the reaction the pH was checked and adjusted to greater than 10 by the addition of a small amount of 20% sodium hydroxide. After all the acid chloride had been added, vigorous stirring was continued for half an hour during which time the crude product separated out. This product was filtered off, washed thoroughly with water and recrystallized from ethanol.
Example 2: 65 grams of sodium N-acetyl-p-aminophenol were slurried with 500 grams of dry benzene and 80 grams of acetyl salicoyl chloride added. The mixture was heated under reflux for four hours and filtered hot. The excess benzene was removed under vacuum and the crude acetyl salicyclic acid ester of N-acetyl-p-aminophenol crystallized from ethanol.
Brand nameBenoral (Sterling Winthrop);Benolat;Benorile;Benotamol;Bentum;Doline;Durium;Duvium;Faw 76;Quinexin;Sinalgin;Spierifex;Triadol;Vetedol;Win 11450;Winolate;Winorlate;Winorylate;Winrolate;Wiolate.
Therapeutic FunctionAnalgesic, Antiinflammatory, Antipyretic
World Health Organization (WHO)Benorilate is the acetylsalicylic ester of paracetamol. See WHO comment for acetylsalicylic acid.
BENORILATE Preparation Products And Raw materials
Raw materialsAcetamide-->Acetylsalicylic acid-->O-ACETYLSALICYLOYL CHLORIDE-->Acetaminophen
Acetaminophen Pentoxyverine Dextromethorphan Procysteine Acetylsalicylic acid Nisoldipine Digitoxin Clofibrate Glucosamine sulfate Loperamide ASPIRIN ALUMINIUM Ambroxol BENORILATE ACETYLSALICYLIC ACID METHYL ESTER 2-METHOXY-BENZOIC ACID PHENYL ESTER 4-Acetoxyacetanilide 2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Phenyl salicylate

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