4-Aminobenzotrifluoride

4-Aminobenzotrifluoride Basic information
Product Name:4-Aminobenzotrifluoride
Synonyms:TIMTEC-BB SBB003956;P-(TRIFLUOROMETHYL)ANILINE;P-AMINOBENZOTRIFLUORIDE;1-AMINO-4-(TRIFLUOROMETHYL)BENZENE;4-AMINOBENZOTRIFLUORIDE;4-AMINO-A,A,A-TRIFLUOROTOLUENE;A,A,A-TRIFLUORO-P-TOLUIDINE;ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLUIDINE
CAS:455-14-1
MF:C7H6F3N
MW:161.12
EINECS:207-236-5
Product Categories:API intermediates;Fluorochemicals;Pharmaceutical Intermediate;Anilines, Aromatic Amines and Nitro Compounds;amine;Amines;Aromatics;Mutagenesis Research Chemicals;bc0001;455-14-1
Mol File:455-14-1.mol
4-Aminobenzotrifluoride Structure
4-Aminobenzotrifluoride Chemical Properties
Melting point 3-8 °C
Boiling point 83 °C12 mm Hg(lit.)
density 1.283 g/mL at 25 °C(lit.)
refractive index n20/D 1.483(lit.)
Fp 188 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Liquid
pka2.45(at 25℃)
color Clear colorless to yellow
Specific Gravity1.283
Water Solubility <0.1 g/100 mL
Sensitive Air Sensitive
BRN 1564853
InChIKeyODGIMMLDVSWADK-UHFFFAOYSA-N
LogP1.95 at 20℃
CAS DataBase Reference455-14-1(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenamine, 4-(trifluoromethyl)-(455-14-1)
EPA Substance Registry System4-(Trifluoromethyl)aniline (455-14-1)
Safety Information
Hazard Codes T,N,Xi,Xn
Risk Statements 25-36-50/53-36/37/38-33-20/21/22
Safety Statements 26-45-60-61-36/37/39-36
RIDADR UN 2810 6.1/PG 3
WGK Germany 3
RTECS XU9260000
Hazard Note Toxic/Irritant
TSCA T
HazardClass 6.1
PackingGroup III
HS Code 29214300
MSDS Information
ProviderLanguage
4-(Trifluoromethyl)aniline English
SigmaAldrich English
ACROS English
ALFA English
4-Aminobenzotrifluoride Usage And Synthesis
Chemical Propertiesclear colorless to yellow liquid
Uses4-(Trifluoromethyl)aniline was used in the synthesis of 4-(trialkylmethyl)anilines. It was also used as a synthetic building block.
Uses4-Substituted aniline derivatives exert special hematotoxicity on the red blood cells and induce leukocytosis.
DefinitionChEBI: A substituted aniline that is a benzene ring substituted with an amino group at position 1 and a trifluoromethyl group at position 4.
Synthesis Reference(s)The Journal of Organic Chemistry, 54, p. 2873, 1989 DOI: 10.1021/jo00273a020
General DescriptionPharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
2-nitro-5-aminobenzotrifluoride (intermediate of flutamide) 2-ACETAMIDO-5-AMINOBENZOTRIFLUORIDE 4-AMINOBENZOTRIFLUORIDE-3-ISOBUTYLPYRIDINE 2,3,5,6-TETRAFLUORO-4-HYDRAZINOBENZOTRIFLUORIDE 5-Acetylamino-2-AminoBenzoTrifluoride M-AMINOBENZOTRIFLUORIDE 4-CHLORO-3-AMINOBENZOTRIFLUORIDE 2-Chloro-6-Aminobenzotrifluoride 3-CHLORO-4-AMINOBENZOTRIFLUORIDE 2-CHLORO-5-AMINOBENZOTRIFLUORIDE,6-Chloro-3-aminobenzotrifluoride,2-CHLORO-5-AMINOBENZOTRIFLUORIDE 98% 5-NITRO-2-AMINOBENZOTRIFLUORIDE 3-Fluoro-4-Aminobenzotrifluoride Trifluoromethyl 3-AMINOBENZOTRIFLUORIDE, 1X1ML, MEOH, 20 00UG/ML 4-AMINO-3,5-DINITROBENZOTRIFLUORIDE 3-NITRO-4-AMINOBENZOTRIFLUORIDE 5-ACETAMIDO-2-AMINOBENZOTRIFLUORIDE 2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide

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