ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Quinoline compounds 4-Hydroxyquinoline

4-Hydroxyquinoline

4-Hydroxyquinoline Basic information
Product Name:4-Hydroxyquinoline
Synonyms:QUINOLIN-4-OL;QUINOLIN-4(1H)-ONE;KYNURINE;4-hydroxy-quinolin;1H-Quinolin-4-one;Quinoline, 4-hydroxy-;4-Hydroxyquinoline98%;4-Quinolinol,4-Hydroxyquinoline
CAS:611-36-9
MF:C9H7NO
MW:145.16
EINECS:210-268-2
Product Categories:Building Blocks;C8 to C10;Quinoline&Isoquinoline;Quinolines;Chemical Synthesis;Heterocyclic Building Blocks;Alcohols and Derivatives;Heterocycles;Quinolines, Quinazolines and derivatives;Heterocyclic Series;Hydroxyquinolines;quinoline
Mol File:611-36-9.mol
4-Hydroxyquinoline Structure
4-Hydroxyquinoline Chemical Properties
Melting point 200-202 °C(lit.)
Boiling point 264.27°C (rough estimate)
density 1.1555 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in methanol.
form Crystalline Powder or Needles
pka2.23, 11.28(at 20℃)
color Light beige to yellow
Water Solubility 4.8g/L(15 ºC)
BRN 1524969
InChIKeyPMZDQRJGMBOQBF-UHFFFAOYSA-N
LogP2.450 (est)
CAS DataBase Reference611-36-9(CAS DataBase Reference)
NIST Chemistry Reference4-Quinolinol(611-36-9)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS VC4070000
HS Code 29334900
MSDS Information
ProviderLanguage
4-Quinolinol English
SigmaAldrich English
ACROS English
ALFA English
4-Hydroxyquinoline Usage And Synthesis
Chemical PropertiesLIGHT BEIGE TO YELLOWISH CRYST. POWDER OR NEEDLES
Uses4-Hydroxyquinolineis a hydroxylated quinoline derivative with antimicrobial activity. 4-Hydroxyquinoline showed growth-inhibitory effects against intestinal bacteria. 4-Hydroxyquinoline act as sacrifi cial scavengers of the photogenerated oxygen species and has been shown to prevent the photodegradation of riboflavin.
Uses4-Hydroxyquinoline is a medical raw material.
DefinitionChEBI: A monohydroxyquinoline carrying a hydroxy group at position 4.
Synthesis Reference(s)Journal of the American Chemical Society, 68, p. 1264, 1946 DOI: 10.1021/ja01211a038
General Description4-Quinolinol (4-quinolone) is a quinolone compound which forms the core moiety of antibacterials such as norfloxacin, nalidixic acid, ciprofloxacin and cinoxacin.
Biological Activity4-hydroxyquinoline is a hydroxylated quinoline derivative with antimicrobial activity. it shows growth-inhibitory effects against intestinal bacteria. it also can be used as sacrificial scavengers of the photogenerated oxygen species.
4-Hydroxyquinoline Preparation Products And Raw materials
Preparation Products3,4-DIAMINOQUINOLINE-->4-AMINO-3-NITROQUINOLINE-->4-Chloroquinoline-->4-Chloro-3-nitroquinoline-->Disperse Yellow HG-->DECAHYDRO-QUINOLIN-4-OL HYDROCHLORIDE-->3-NITRO-4-QUINOLINOL-->4-Methoxyquinoline-->Imiquimod-->3-Amino-4-chloroquinoline-->4-Bromoquinoline-->4(1H)-Quinolinone, 3-(hydroxymethyl)--->Pentitol, 1,4-anhydro-2,5-dideoxy-3-S-(3-iodo-4-quinolinyl)-3-thio-
ETHYL 7,8-DICHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLATE 2,4-DIHYDROXYQUINOLINE MONOSODIUM SALT 8-TERT-BUTYL-3-FLUORO-2-HYDROXYQUINOLINE ETHYL 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLATE ETHYL 6,8-DIMETHYL-4-HYDROXYQUINOLINE-3-CARBOXYLATE 8-HYDROXYQUINOLINE-BETA-D-GALACTOPYRANOSIDE Tris(8-hydroxyquinolinato)erbium 8-HYDROXYQUINOLINE HYDROCHLORIDE 4-Hydroxyquinoline BIS(2-METHYL-8-HYDROXYQUINOLINATO)ZINC 8-HYDROXYQUINOLINE, [RING-14C(U)] 2-Quinolinol Copper 8-quinolinolate,W.P. 2,8-Bis(trifluoromethyl)-4-quinolinol 6-Hydroxyquinoline 8-HYDROXYQUINOLINE BASE 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone Quinhydrone
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