ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Tyrosine derivatives AG 18

AG 18

AG 18 Basic information
Product Name:AG 18
Synonyms:RARECHEM AL BX 0069;RG-50810;TYRPHOSTIN RG 50858;TYRPHOSTIN AG 18;TYRPHOSTIN A23;TYRPHOSTIN 23;ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMONITRILE;AG 18
CAS:118409-57-7
MF:C10H6N2O2
MW:186.17
EINECS:
Product Categories:Intracellular Signaling;Protein Kinase;All Inhibitors;Inhibitors;Tyrosine Kinase Inhibitors
Mol File:118409-57-7.mol
AG 18 Structure
AG 18 Chemical Properties
Melting point 225°C
Boiling point 421.1±45.0 °C(Predicted)
density 1.428±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO, ethanol, or DMF
pka7.26±0.18(Predicted)
form Yellow solid
color Yellow
λmax464nm(DMSO)(lit.)
Stability:Store in refrigerator
Safety Information
WGK Germany 3
HS Code 2926.90.5050
MSDS Information
ProviderLanguage
SigmaAldrich English
AG 18 Usage And Synthesis
Chemical PropertiesYellow Powder
UsesA specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).
UsesAG 18 inhibits EGFR with IC50 of 35 μM.
DefinitionChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.
Biological ActivityInhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
Biochem/physiol ActionsTyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
AG 18 Preparation Products And Raw materials
(BENZO[3,4-D]1,3-DIOXOLAN-5-YLMETHYLENE)METHANE-1,1-DICARBONITRILE RARECHEM AL BX 0936 2-[(3-HYDROXY-4,5-DIMETHOXYPHENYL)METHYLENE]MALONONITRILE 2-[(4-HYDROXY-3-IODO-5-METHOXYPHENYL)METHYLENE]MALONONITRILE NS-398 AG 18 TYRPHOSTIN AG 1288 TIMTEC-BB SBB001265 2-[(3-METHOXY-4-([3-(TRIFLUOROMETHYL)BENZYL]OXY)PHENYL)METHYLENE]MALONONITRILE 2-[(3,4-DIHYDROXY-5-METHOXYPHENYL)METHYLENE]MALONONITRILE 2-[(E)-1-(1,3-BENZODIOXOL-5-YL)-3-(DIMETHYLAMINO)-2-PROPENYLIDENE]MALONONITRILE {4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]-3-METHOXYBENZYLIDENE}MALONONITRILE ((3,4,5-TRIMETHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE 2-[1-(1,3-BENZODIOXOL-5-YL)ETHYLIDENE]MALONONITRILE 2-((3-[(DIMETHYLAMINO)METHYL]-4-HYDROXY-5-METHOXYPHENYL)METHYLENE)MALONONITRILE 2-((4-[(2-CHLORO-1,3-THIAZOL-5-YL)METHOXY]-3-METHOXYPHENYL)METHYLENE)MALONONITRILE RARECHEM AL BX 0771 ((4-HYDROXY-3-METHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE
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