3-Aminopyrazole

3-Aminopyrazole Basic information

Product Name:	3-Aminopyrazole
Synonyms:	3-PYRAZOLAMINE;3-AMINO-1H-PYRAZOLE;3-AMINOPYRAZOLE;5-AMINOPYRAZOLE;AKOS B007331;3-Aminopyarazole;pyrazol-3-ylamine;3-AMINOPYROZOLE
CAS:	1820-80-0
MF:	C3H5N3
MW:	83.09
EINECS:	217-338-1
Product Categories:	Building Blocks;C3 to C5;Miscellaneous Reagents;Chemical Synthesis;Heterocyclic Building Blocks;Pyrazoles;Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Amines;Pyrazoles & Triazoles;Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Pyrazoles & Triazoles;bc0001
Mol File:	1820-80-0.mol

3-Aminopyrazole Chemical Properties

Melting point	34-37 °C (lit.)
Boiling point	218 °C/122 mmHg (lit.)
density	1.0248 (rough estimate)
refractive index	1.5060 (estimate)
Fp	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	soluble in Methanol
pka	15.28±0.10(Predicted)
form	Oily Liquid or Crystalline Low Melting Solid
color	White to light yellow
Sensitive	Air & Light Sensitive
BRN	1618
InChIKey	JVVRJMXHNUAPHW-UHFFFAOYSA-N
CAS DataBase Reference	1820-80-0(CAS DataBase Reference)
NIST Chemistry Reference	3(5)-aminopyrazole(1820-80-0)

Safety Information

Hazard Codes	C,Xi
Risk Statements	22-34-36/37/38
Safety Statements	26-36/37/39-45-27
RIDADR	UN 3263 8/PG 2
WGK Germany	3
F	8-10-23
Hazard Note	Corrosive
HazardClass	IRRITANT
HazardClass	8
PackingGroup	Ⅱ
HS Code	29331990

MSDS Information

Provider	Language
1H-Pyrazol-3-amine	English
SigmaAldrich	English
ACROS	English
ALFA	English

3-Aminopyrazole Usage And Synthesis

Chemical Properties	3-Aminopyrazole is Low-Melting Yellow Solid
Uses	Employed in a one-pot synthesis of pyrazolopyrimidines.1
Uses	3-Aminopyrazole was used in the spectroscopic characterization of ferrocenoyl peptides via ¹H-NMR spectroscopy. It was also used in the synthesis of: symmetrical dialkylpyrazolo[1,5-a]pyrimidines via condensation with symmetrical β-diketones 3,4-annelated coumarins heterocyclic compounds of pharmaceutical interest pyrazolopyrimidines
Uses	3-Aminopyrazole is used in the preparation of heterocyclic compounds of pharamaceutical interest
General Description	3-Aminopyrazole is a heteroarylamine.
Synthesis	The synthesis of 3-Aminopyrazole is as follows:A solution of 50 mg (0.34 mmol) of 3-oxo-3-phenylpropanenitrile and 11.6 mg (0.36 mmol) of hydrazine and 0.024 mL of acetic acid (0.37 mmol) in 3 mL of anhydrous ethanol was heated at 60° C for 24 hr. The mixture was cooled to ambient temperature and the solvent removed in vacuo. The residue was taken up in ethyl acetate, washed with saturated sodium bicarbonate. The organic layer was washed with brine and dried over MgSO4, filtered and evaporated. The solid residue waswashedwithethyl ether and dried in vacuo to give 45 mg (82%) of 3-phenyl-1H-pyrazol-5-amine.

3-Aminopyrazole Preparation Products And Raw materials

Preparation Products

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE-->1H-Pyrazolo[3,4-b]pyridin-3-amine-->1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO--->3-NITRO-1H-PYRAZOLO[3,4-B]PYRIDINE-->8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE-->1H-PYRAZOLO[3,4-B]PYRIDINE-->5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE-->3-Acetylaminopyrazole-->3-Amino-4-bromopyrazole-->5-Nitro-1H-pyrazolo[3,4-b]pyridine-->3-AMino-4-iodo-1H-pyrazole, 97%-->1174229-22-1-->1-(4-FLUORO-BENZYL)-1H-PYRAZOL-3-YLAMINE-->1-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-amine-->7-Methylpyrazolo[1,5-a]pyriMidin-5(4H)-one

3-cyanomethyl-4-cyano-5-aminopyrazol 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 3-Aminopyrazole Aminopyrazine Metazachlor Pyraclostrobin Triallylamine 3-AMINOPYRAZOLE-4-CARBOXYLIC ACID Dibenzylamine Triethylamine 5-AMINO-1-PHENYLPYRAZOLE Zolpidem Bis(2-ethylhexyl)amine Zolpidem tartrate 5-AMINO-4-CYANO-1-(2-HYDROXYETHYL)PYRAZOLE 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 3-Amino-4-pyrazolecarboxamide hemisulfate Triethanolamine

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