Phenytoin sodium

Phenytoin sodium Basic information
Product Name:Phenytoin sodium
Synonyms:solantoin;solantyl;5,5-DIPHENYLHYDANTOIN SODIUM;5,5-DIPHENYLHYDANTOIN SODIUM SALT;4-imidazolidinedione,5,5-diphenyl-monosodiumsalt;5,5-diphenyl-hydantoimonosodiumsalt;5,5-diphenylhydantoinsodiumsigmaultra;dilantinsodium
CAS:630-93-3
MF:C15H13N2NaO2
MW:276.27
EINECS:211-148-2
Product Categories:RONDOMYCIN;API intermediate;Classes of Metal Compounds;Na (Sodium) Compounds (excluding simple sodium salts);Typical Metal Compounds;Sodium channel
Mol File:630-93-3.mol
Phenytoin sodium Structure
Phenytoin sodium Chemical Properties
storage temp. Inert atmosphere,Room Temperature
solubility aqueous base: soluble
form Crystalline Powder
color White to almost white
Merck 14,7322
BCS Class2
Stability:Hygroscopic
InChIKeyFJPYVLNWWICYDW-UHFFFAOYSA-M
CAS DataBase Reference630-93-3(CAS DataBase Reference)
EPA Substance Registry SystemDiphenylhydantoin sodium (630-93-3)
Safety Information
Hazard Codes Xn
Risk Statements 22-43-62-63
Safety Statements 22-36/37/39-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS MU1400000
HazardClass 6.1(b)
PackingGroup III
HS Code 29332100
ToxicityLD50 orally in mice: 490 mg/kg (Fink, Swinyard)
MSDS Information
ProviderLanguage
5,5-Diphenylhydantoin sodium salt English
SigmaAldrich English
Phenytoin sodium Usage And Synthesis
Chemical PropertiesWhite or almost white, crystalline powder, slightly hygroscopic.
Usesantibacterial
UsesAntiepileptic
Uses5,5-Diphenylhydantoin sodium salt has been used:
  • in the cream preparation for treating burn wounds
  • in seizure behavior testing as an anticonvulsant in Drosophila
  • in in vivo embryo toxicity test in mouse embryonic stem cells

Brand nameDiphenylan (Lannett); Phenytek (Mylan); Phenytex (Watson) [Name previously used: Diphenylhydantoin Sodium.].
General DescriptionPhenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt.
Clinical UsePhenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.
Safety ProfileConfirmed carcinogen. Experimental teratogen. Other experimental reproductive effects. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: anorexia, respiratory depression, nausea or vomiting, hemorrhage, dermatitis, and endocrine effects. Mutation data reported. An anticonvulsant and cardiac depressant used for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits very toxic fumes of NOx and Na2O.
CarcinogenicityPhenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals.
Phenytoin sodium Preparation Products And Raw materials
Raw materialsBenzil
Sodium benzoate Diphenylphosphine Sodium acetate DIPHENYLCYCLOPROPENONE Phenytoin sodium sodium Imidazolidinyl urea Diphenylmethane Sodium chloride D(-)-Phenylglycinamide Chlorodiphenylphosphine (D)-5-METHYLHYDANTOIN 5-Phenylhydantoin Sodium citrate (R)(+)-ALPHA-PHENETHYLUREA Sodium bicarbonate Sodium hydroxide 2,2-DIPHENYLACETAMIDE

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.