Tris(dibenzylideneacetone)dipalladium-chloroform adduct

Tris(dibenzylideneacetone)dipalladium-chloroform adduct Basic information
Reaction
Product Name:Tris(dibenzylideneacetone)dipalladium-chloroform adduct
Synonyms:TRIS(DIBENZYLIDENEACETONE)(CHLOROFORM)-DI-PALLADIUM(0);TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM(0) CHLOROFORM ADDUCT;TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM-CHLOROFORM ADDUCT;TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM CHLOROFORM COMPLEX;DIPALLADIUM(0)TRIS(DIBENZYLIDENEACETONE)-CHLOROFORM ADDUCT;DI-PALLADIUM-TRIS(DIBENZYLIDENEACETONE)CHLOROFORM COMPLEX;Dipalladiumtris(dibenzylideneacetone) chloroform adduct;TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM(0) CHLOROFORM ADDUCT 98+%
CAS:52522-40-4
MF:C52H31Cl3O3Pd2
MW:1023.01
EINECS:610-856-2
Product Categories:organometallic complexes;Metal Compounds
Mol File:52522-40-4.mol
Tris(dibenzylideneacetone)dipalladium-chloroform adduct Structure
Tris(dibenzylideneacetone)dipalladium-chloroform adduct Chemical Properties
Melting point 131-135 °C(lit.)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Crystalline Powder
color Purple to black
Water Solubility Soluble in organic solvents. Insoluble in water.
Sensitive Air & Moisture Sensitive
InChIKeyNLYJPAJWGANOKG-CXKPDERJSA-N
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-38-40-48/20/22-36/37/38
Safety Statements 36/37-37/39-26
WGK Germany 3
TSCA No
HS Code 28439000
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Tris(dibenzylideneacetone)dipalladium-chloroform adduct Usage And Synthesis
Reaction
  1. Used for Pd-catalyzed asymmetric arylation, vinylation, and Allenylation of tert-cyclobutanols via enantioselective C−C Bond cleavage.
  2. Used for synthesis of chiral chromans through the Pd-catalyzed asymmetric allylic alkylation (AAA).
  3. Catalyst for double N-arylation of primary amines to synthesize multisubstituted carbazoles from 2,2‘biphenylylene ditriflates.
  4. Paladium catalyst for regioand enantioselective allylic alkylation of ketones through allyl enol carbonates.
  5. Used for Pd-catalyzed enantioselective C-3 allylation of 3-substituted-1H-indoles using trialkylboranes.
  6. Used for enantioselective construction of spirocyclic oxindolic cyclopentanes by Pd-catalyzed trimethylenemethane-[3+2]-cycloaddition.
  7. Used for Pd-catalyzed insertion of α-diazoesters into vinyl halides to generate α,β-unsaturated γ-amino Esters.
  8. Pd catalyst for decarboxylative asymmetric allylic alkylation of enol carbonates.
  9. Palladium catalyst for asymmetric addition of oxindoles and allenes.
  10. Catalyst for diastereoand enantioselective formal [3+2]-cycloaddition between substituted vinylcyclopropanes and electron-deficient olefins.
  11. Used for Pd-catalyzed asymmetric decarboxylative cycloaddition of vinylethylene carbonates with Michael sacceptors.
  12. Catalyst for enantioselective [6+4] cycloaddition of vinyl oxetanes with azadienes to access ten-membered heterocycles.
Reactions of 52522-40-4_1
Reactions of 52522-40-4_2
Reactions of 52522-40-4_3
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Reactions of 52522-40-4_5



Chemical Propertiespurple to black crystalline powder
Usessuzuki reaction
UsesTris(dibenzylideneacetone)dipalladium(0)-chloroform adduct is a catalyst that is used in the preparation of anticancer activity of amino vinylindoles via palladium catalyzed coupling of hydrazone, haloindoles and amines.
ApplicationTris(dibenzylideneacetone)dipalladium-chloroform adduct (Pd2dba3·CHCl3) was used in the following studies:
To compose the catalytic system for the preparation of homoallylpalladium complexes.These complexes underwent in situ Stille type cross coupling with various vinyltin reagents to afford the cyclized products bearing allyl appendages.
As palladium source in the asymmetric transformations of 3,4-epoxy-1-butene.
As catalyst for the Heck cross-coupling reaction of iodobenzene with styrene.
As cyclization catalyst.
As catalyst for [2+2+2] cycloaddtion of didehydrotriphenylenes to the corresponding extended triphenylenes.
As catalyst for the carbonylation of b,b-imidoyl iodides to the corresponding imidate esters used, in turn, to prepare cyclic, quaternary amino acids.
General DescriptionTris(dibenzylideneacetone)dipalladium(0)-chloroform adduct (Pd2dba3·CHCl3) is reported to serve as effective precatalysts, or precursors to the active Pd(0) catalyst.
Biological ActivityN -myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo . Also used as a cyclization catalyst.
Tris(dibenzylideneacetone)dipalladium-chloroform adduct Preparation Products And Raw materials
Raw materialsEthanol-->Sodium hydroxide-->Methanol-->Diethyl ether-->Dichloromethane-->Toluene-->Chloroform-->Acetone-->Ammonium chloride-->Acetonitrile-->Sodium acetate-->Benzaldehyde-->Palladium chloride-->tert-Butyl methyl ether
TRIS(DIMETHYLAMINO)SILANE TRIS(DIMETHYLAMINO)ANTIMONY Tris(dibenzylideneacetone)dipalladium trans,trans-Dibenzylideneacetone Benzyl chloride Benzyltriethylammonium chloride Tris(dibenzylideneacetone)dipalladium-chloroform adduct Benzalacetone Phenylacetone Dibenzylideneacetone Bis(dibenzylideneacetone)palladium Benzyltrimethylammonium chloride Chloroform Tricine Palladium Benzylacetone Tris(hydroxymethyl)aminomethane BUFFER SOLUTION PH = 6,00 (20 °C) (POTASSIUM DIHYDROGEN PHOSPHATE/SODIUM HYDROXIDE)

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