Phenformin hydrochloride

Phenformin hydrochloride Basic information
Product Name:Phenformin hydrochloride
Synonyms:1-(diaminomethylene)-2-phenethylguanidine hydrochloride;1-(diaminomethylene)-2-phenethyl-guanidine hydrochloride;1-(diaminomethylidene)-2-phenethylguanidine hydrochloride;1-(diaminomethylidene)-2-phenethyl-guanidine hydrochloride;1-Fenetilbiguanide cloridrato [Italian];1-Phen;meltrol;n-(2-phenylethyl)-imidodicarbonimidicdiamidmonohydrochloride
CAS:834-28-6
MF:C10H16ClN5
MW:241.72
EINECS:212-637-3
Product Categories:Inhibitors;API;Intermediates & Fine Chemicals;Pharmaceuticals;VIAGRA
Mol File:834-28-6.mol
Phenformin hydrochloride Structure
Phenformin hydrochloride Chemical Properties
Melting point 175-178°C
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Methanol (Slightly), Water (Slightly)
form neat
color White to Off-White
Water Solubility >=10 g/100 mL at 21 ºC
CAS DataBase Reference834-28-6(CAS DataBase Reference)
EPA Substance Registry SystemPhenformin hydrochloride (834-28-6)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
WGK Germany 3
RTECS DU2200000
HS Code 29252900
ToxicityLD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske)
MSDS Information
ProviderLanguage
1-Phenethylbiguanide hydrochloride English
SigmaAldrich English
Phenformin hydrochloride Usage And Synthesis
DescriptionPhenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.
Chemical PropertiesWhite Crystalline Solid
UsesIt is an anti-diabetic drug from the biguanide class.
Useserectile dysfunction therapy
Brand nameDBI (Ciba-Geigy).
General DescriptionWhite solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis.
Air & Water ReactionsWater soluble.
Reactivity ProfilePhenformin hydrochloride gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
Fire HazardFlash point data for Phenformin hydrochloride are not available; however, Phenformin hydrochloride is probably combustible.
Safety ProfilePoison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Phenformin hydrochloride Preparation Products And Raw materials
Raw materialsDicyandiamide
Benzydamine hydrochloride Phenazopyridine hydrochloride Epirubicin hydrochloride Benzhexol hydrochloride Gliclazide Diphenhydramine Hydrochloride Amlodipine Metformin Biguanide Phenformin hydrochloride Topotecan hydrochloride Sibutramine hydrochloride Tramadol hydrochloride Phenformin hydrochloride CP2000 1-AdaMantanethylaMine Hydroxylamine hydrochloride IMINOCTADINE Biguanide hydrochloride

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