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| | (16R)-18,19-Didehydro-17-hydroxycorynan-16-carboxylic acid methyl ester Basic information |
| Product Name: | (16R)-18,19-Didehydro-17-hydroxycorynan-16-carboxylic acid methyl ester | | Synonyms: | (16R)-18,19-Didehydro-17-hydroxycorynan-16-carboxylic acid methyl ester;Sitsirikine;(16R)-18,19-Didehydro-17-hydroxy-17,18-secoyohimban-16-carboxylic acid methyl ester;Sitsirikin;16R-sitsirikine;Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethenyl-1,2,3,4,6,7,12,12b-octahydro-α-(hydroxymethyl)-, methyl ester, (αR,2S,3R,12bS)- | | CAS: | 1245-00-7 | | MF: | C21H26N2O3 | | MW: | 354.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1245-00-7.mol |  |
| | (16R)-18,19-Didehydro-17-hydroxycorynan-16-carboxylic acid methyl ester Chemical Properties |
| Melting point | 239-241℃ (Decomposition) | | Boiling point | 545.4±50.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | pka | 14.30±0.10(Predicted) |
| | (16R)-18,19-Didehydro-17-hydroxycorynan-16-carboxylic acid methyl ester Usage And Synthesis |
| Description | One of the numerous alkaloids isolated from Vinca species, this base occurs in V. rosea L. and forms colourless crystals from MeOH. It is laevorotatory with[α]26D - 58° (MeOH) and when crystallized from Me2CO forms crystals containing solvent of crystallization, m.p. 181°C. The ultraviolet spectrum in MeOH has absorption maxima at 226, 282 and 290 mf.1. The alkaloid contains a primary alcoholic group and an imino group and yields the hemisulphate, m.p. 239- 241°C (dec.); the picrate, m.p. 226-8°C (dec.) and the O-acetate, m.p. 198°C;[α]26D- 26° (MeOH). | | References | Svoboda et al., J. Pharm. Sci., 50,409 (1961)
Kutney, Brown., Tetrahedron Lett., 1815 (1963) |
| | (16R)-18,19-Didehydro-17-hydroxycorynan-16-carboxylic acid methyl ester Preparation Products And Raw materials |
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