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| | Triethanolamine borate Basic information |
| Product Name: | Triethanolamine borate | | Synonyms: | BORATRANE;2,8,9-TRIOXA-5-AZA-1-BORABICYCLO(3.3.3)UNDECANE;Ethanol, 2,2',2''-nitrilotris-, cyclic ester with boric acid (H3BO3) (1:1);ethanol,2,2’,2’’-nitrilotri-,borate;BRN 0774536;2,2μ,2μμ-Nitrilotriethyl borate, Boratrane;1-Bora-2,8,9-trioxa-5-azabicyclo[3.3.3]undecane;1-Bora-5-aza-2,8,9-trioxabicyclo[3.3.3]undecane | | CAS: | 283-56-7 | | MF: | C6H12BNO3 | | MW: | 156.98 | | EINECS: | 206-003-5 | | Product Categories: | B (Classes of Boron Compounds);Boric Acid Esters;Boric Acid Triesters | | Mol File: | 283-56-7.mol |  |
| | Triethanolamine borate Chemical Properties |
| Melting point | 235-237 °C(lit.) | | Boiling point | 149.6±39.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | Room Temperature, under inert atmosphere | | solubility | slightly soluble in acetone, benzene | | form | Powder | | pka | 6.40±0.20(Predicted) | | color | white | | Odor | odorless | | BRN | 774536 | | InChIKey | NKPKVNRBHXOADG-UHFFFAOYSA-N | | CAS DataBase Reference | 283-56-7 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37 | | WGK Germany | 3 | | RTECS | YJ8968050 | | F | 10-21 | | HS Code | 29163990 | | Toxicity | LD ivn-mus: >100 mg/kg EJMCA5 13,207,78 |
| | Triethanolamine borate Usage And Synthesis |
| Chemical Properties | White to off-white solid | | Uses | Triethanolamine Borate is an intermediate in the synthesis of Silatrane (S433000) which can be used as a reversible cholinesterase inhibitor. Silatrane and its derivatives can also be used as antitumor agents. | | Preparation | triethanolamine borate synthesis: Adding trimethyl borate into the reaction bottle62.7g (0.6mol), 74.6g (0.5mol) of triethanolamine and 300g of toluene are slowly heated to reflux for 1 hour at room temperature, then distillate is distilled out under normal pressure (65-100°C) while reaction is carried out, sampling is carried out by GC detection, after the reaction is finished, reduced pressure concentration is carried out until no liquid distillation is carried out, acetonitrile is added for recrystallization, filtration and drying are carried out, 68g of white solid is obtained, HPLC (high performance liquid chromatography) is 98.8%, and the yield is 86.6%. | | General Description | Triethanolamine borate can be formed from the 1:1 aqueous solution of boric acid and triethanolamine. It is used as buffer. | | Safety Profile | A poison by intravenous route.When heated to decomposition it emits toxic fumes of NOx. |
| | Triethanolamine borate Preparation Products And Raw materials |
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