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| | Tropine Basic information |
| | Tropine Chemical Properties |
| Melting point | 50-60 °C(lit.) | | Boiling point | 233 °C(lit.) | | density | 1.045 g/mL at 25 °C(lit.) | | refractive index | 1.4811 (estimate) | | Fp | 232-234°C | | storage temp. | Inert atmosphere,2-8°C | | solubility | H2O: 0.1 g/mL, clear | | form | Crystalline Powder | | pka | 3.80(at 15℃) | | color | White to slightly yellow | | PH | 12 (100g/l, H2O, 20℃) | | Water Solubility | 100 g/L (20 ºC) | | Sensitive | Hygroscopic | | Merck | 14,9781 | | BRN | 80188 | | InChIKey | CYHOMWAPJJPNMW-JIGDXULJSA-N | | LogP | -0.100 (est) | | CAS DataBase Reference | 120-29-6(CAS DataBase Reference) | | NIST Chemistry Reference | Tropine(120-29-6) | | EPA Substance Registry System | 8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, (3-endo)- (120-29-6) |
| Hazard Codes | Xi,Xn | | Risk Statements | 26/28-20/22 | | Safety Statements | 22-24/25 | | RIDADR | 1544 | | WGK Germany | 3 | | RTECS | YM3875000 | | F | 3 | | Hazard Note | Irritant | | TSCA | Yes | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29399990 |
| | Tropine Usage And Synthesis |
| Chemical Properties | white to slightly yellow crystalline powder | | Uses | Tropine as an oxidative product of Tropane, used to synthesize alkaloid derivatives. Benzatropine and etybenzatropine are derivatives of tropine. It is also a building block of atropine, an anticholinergic drug prototypical of the muscarinic antagonist class. | | Uses | Tropine is an oxidative product of Tropane, used to synthesize alkaloid derivatives.
| | Definition | ChEBI: A derivative of tropane having a hydroxy group at the 3-position. | | Purification Methods | Distil 3-tropanol in steam and crystallise it from Et2O or toluene/pet ether. It sublimes at 60o/0.1mm. Hygroscopic. The hydrochloride has m 280o (from EtOH/Et2O). [Beilstein 21 H 16, 21 I 197, 21 II 17, 21 III/IV 168, 21/1 V 219.] |
| | Tropine Preparation Products And Raw materials |
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