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| | LAVENDUSTIN A Basic information |
| | LAVENDUSTIN A Chemical Properties |
| Melting point | 205-215 °C | | Boiling point | 741.7±60.0 °C(Predicted) | | density | 1.495±0.06 g/cm3(Predicted) | | RTECS | DG8578950 | | storage temp. | −20°C | | solubility | DMSO: soluble | | pka | 2.31±0.10(Predicted) | | form | crystalline | | color | Yellow to brown | | Sensitive | Air Sensitive | | Stability: | Moisture Sensitive: Hygroscopic | | CAS DataBase Reference | 125697-92-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26 | | WGK Germany | 3 | | HS Code | 29225000 |
| | LAVENDUSTIN A Usage And Synthesis |
| Description | Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis. | | Chemical Properties | Off-White Solid | | Uses | A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide. | | Definition | ChEBI: 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid is an aromatic amine. | | Biological Activity | Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 11 nM). Inhibits p60 c-src with an IC 50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC 50 > 100 μ M). | | target | EGFR | PKC | PI3K | Calcium Channel |
| | LAVENDUSTIN A Preparation Products And Raw materials |
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