Hydroxyapatite

Hydroxyapatite Basic information
Product Name:Hydroxyapatite
Synonyms:CALCIUM PHOSPHATE, HYDROXIDE PURIFIED;Hydroxyapatite: (Calcium hydroxyapatite);Calcium phosphate hydroxide, Durapatite, Hydroxylapatite;CALCIUM PHOSPHATE, HYDROXIDE REAGENT;Hydroxyapatite,Calcium hydroxyphosphate, Calcium phosphate tribasic, HAp, Hydroxylapatite;Hydroxylapatite, for analysis 25GR;apatite,hydroxy;Bonedust
CAS:1306-06-5
MF:Ca5HO13P3
MW:502.31
EINECS:215-145-7
Product Categories:raw materials;Inorganics
Mol File:1306-06-5.mol
Hydroxyapatite Structure
Hydroxyapatite Chemical Properties
Melting point 1100 °C(lit.)
density 3.076 g/cm3(Temp: 18 °C)
storage temp. 2-8°C
solubility H2O: 0.3 mg/mL, clear, colorless
form solid
color White
Water Solubility insoluble H2O [MER06]
Merck 13,3500
CAS DataBase Reference1306-06-5(CAS DataBase Reference)
EPA Substance Registry SystemHydroxylapatite (Ca5(OH)(PO4)3) (1306-06-5)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS MY8434000
3-10
TSCA Yes
HS Code 28352600
Hazardous Substances Data1306-06-5(Hazardous Substances Data)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Hydroxyapatite Usage And Synthesis
DescriptionCalcium hydroxyapatite has a unique structure in that it is conductive along the hydroxide channels. OH- ions lie at (1/4/,1/4,1/4) and (3/4/,3/4,3/4) on the c-axis and charge-carrying protons are responsible for the observed conductivities in M10(PO4)6(OH)2. The H+ migration between the electroattractive ion (O2) to give molecular H2O in matrix channels carries charge and the resulting conductivity.
The unit cell consists of two triangular prismatic subcells forming a rhombic prism with vertical sides. There are two horizontal mirror planes at the OH levels of 1/4 and 3/4 of the c-axis. In addition, there is a center of inversion exactly in the center of each vertical face of each subcell.
Chemical PropertiesTricalcium phosphate is an odorless and tasteless powder that is stable in air. Tribasic calcium phosphate consists of a variable mixture of calcium phosphates having the approximate composition of 10CaO·3P2O5·H2O.
Chemical Propertieswhite powder
OccurrenceOccurs in nature as the minerals: oxydapatit, voelicherite, whitlockite.
UsesIn the 1970s, it was found that sintered calcium hydroxyapatite, (Ca10(PO4)6(OH)2 (abbreviated as CaHap), possessed excellent biocompatibility and nontoxicity with femur and mandible bones. Since then, CaHap has been used as a biomaterial for artificial teeth and bones and as a filler for cements and polymers. Today, bone fillers made of CaHap are widely used in the medical and dental fields. In the 1980s, it was found that sintered CaHap has a good compatibility with skin tissues. Hence, percutaneous devices based on CaHap have been developed and applications have included continuous ambulatory peritoneal dialysis and intravenous hyperalimentation systems, blood pressure measurement and blood access for nutrition. Recently, many researchers have studied the chemistry of apatites, particularly CaHap, and have found various applications, such as artificial teeth and bones, ion exchangers, adsorbents for chromatography to separate proteins and enzymes, catalysts, ionic conductors, temperature and gas sensors, etc.
UsesProsthetic aid (artificial bone and teeth).
UsesHydroxyapatite and tricalcium phosphate are bioactive ceramic materials and they find applications as bone grafts, fillers and coating material for metal implants.
PreparationThe technical product is also known as “bone ash.” Commercial preparation from phosphate rock.
DefinitionThe major constituent of bone and tooth mineral. It is finely divided, crystalline, nonstoichiometric material rich in surface ions (carbonate, magnesium, citrate), which are readily replaced by fluoride ion, thus affording protection to the teeth.
Brand nameAlveograf (Sterling Winthrop); Periograf (Sterling Winthrop).
General DescriptionBone and tooth implant materials have been prepared from polycrystalline hydroxyapatite. The compressive, flexural, torsional and dynamic torsional strengths of polycrystalline hydroxyapatite were investigated. Electrophoretic deposition of hydroxyapatite on to flat titanium plate material has been studied.
Flammability and ExplosibilityNotclassified
Pharmaceutical ApplicationsModified hydroxylapatite, also frequently called hydroxyapatite and better known as bone mineral, makes up ~50% of our bones. Hydroxylapatite is a natural form of the mineral calcium apatite, whose formula is usually denoted as Ca10(PO4)6(OH)2. Modifications of hydroxylapatite can also be found in the teeth, and a chemically identical substance is often used as filler for replacement of bones, and so on. Nevertheless, despite similar or identical chemical compositions, the response of the body to these compounds can be quite different.
Hydroxyapatite Preparation Products And Raw materials
Preparation ProductsCalcium phosphate monobasic-->Gelatin-->L-Tyrosine
HYDROXYAPATITE TYPE I HYDROXYLAPATITE, FAST FLOW Hydroxylapatite,type Ⅲ CALCIUM PHOSPHATE TRIBASIC - REAGENT strontium hydroxyapatite APATITE hydroxyapatite-beta tricalcium phosphate Hydroxylapatite,typeⅡ hydroxyapatite-titanium alloy samarium hydroxyapatite Hydroxyapatite preparation { HYDROXYLAPATITE, HIGH RES rhenium hydroxyapatite CALCIUM phosphate Calcium phosphate tribasic USP23/NF18,BP98 calcium polyacrylate-hydroxyapatite cement fluor-hydroxylapatite Tricalcium Phosphate

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