ChemicalBook Product Catalog Natural Products Alkaloids Dicentrin

Dicentrin

Dicentrin Basic information
Description Anti-cancer Activity
Product Name:Dicentrin
Synonyms:DICENTRINE95%;dicentrine;(7aS)-6,7,7a,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline;1,2-Methylenedioxy-9,10-dimethoxyaporphine;5H-Benzo[G]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7A,8-tetrahydro-10,11-dimethoxy-7-methyl-, (S)-;6A.alpha.-Aporphine, 9,10-dimethoxy-1,2-(methylenedioxy)-;9,10-Dimethoxy-1,2-(methylenedioxy)aporphine;Nsc406035
CAS:517-66-8
MF:C20H21NO4
MW:339.39
EINECS:
Product Categories:
Mol File:517-66-8.mol
Dicentrin Structure
Dicentrin Chemical Properties
Melting point 177-178℃
Boiling point 481℃
density 1.266
refractive index 1.6250 (estimate)
Fp 143℃
storage temp. 4°C, protect from light
solubility Soluble in DMSO
pka6.65±0.20(Predicted)
Safety Information
MSDS Information
Dicentrin Usage And Synthesis
Description

D-Dicentrine is an aporphinic alkaloid found in several plant species, mainly from family Lauraceae, including Lindera megaphylla. D-Dicentrine shows antinociceptive activity in a mouse model of pain. It probably acts via a TRPA1-dependent mechanism. D-Dicentrine is an alpha 1-adrenoceptor antagonist effective against human hyperplastic prostates.

Anti-cancer Activity

D-Dicentrine, a naturally occurring aporphine type isoquinoline alkaloid, isolated from the root of Lindera megaphylla Hemsl. (Lauraceae), was evaluated for its potential anti-cancer activity. Huang RL etc. found d-dicentrine significantly inhibited the growth of human hepatoma cell line HuH-7 by delaying its doubling time in tissue culture. An in vitro colony forming assay showed that d-dicentrine decreased the colony formation efficiency in both hepatoma cell lines, HuH-7 and MS-G2, used in our study.

Usesd-Dicentrine is a natural aporphine alkaloid extracted from the root of L. megaphylla which displays antitumor effects through inhibition of topoisomerase II.
DefinitionChEBI: Dicentrine is an aporphine alkaloid.
Dicentrin Preparation Products And Raw materials
Daurinoline Xanthiazone veratramine VERATRIDINE [7aS,(+)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline Xanthiside L-Hyoscyamine daurisoline CURINE 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one VERATRINE corydalmine menisdaurin
Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.