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| | MRS 2578 Basic information |
| Product Name: | MRS 2578 | | Synonyms: | N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA];MRS 2578;1,4-DI[3-(3-ISOTHIOCYANATOPHENYL)THIOUREIDO]BUTANE;N',N'''-butane-1,4-diylbis[1-(3-isothiocyanatophenyl)(thiourea)];Thiourea, N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)-;MRS 2578;MRS-2578; MRS2578;MRS-2578; MRS2578;CS-1109 | | CAS: | 711019-86-2 | | MF: | C20H20N6S4 | | MW: | 472.67 | | EINECS: | 200-258-5 | | Product Categories: | Inhibitors | | Mol File: | 711019-86-2.mol |  |
| | MRS 2578 Chemical Properties |
| Melting point | 170 - 173°C | | Boiling point | 652.7±65.0 °C(Predicted) | | density | 1.31 | | storage temp. | 2-8°C | | solubility | DMSO: ~17 mg/mL | | pka | 11.80±0.70(Predicted) | | form | solid | | color | white | | InChIKey | QOHNRGHTJPFMSL-UHFFFAOYSA-N |
| | MRS 2578 Usage And Synthesis |
| Description | MRS2578 is an antagonist of the purinergic P2Y6 receptor (IC50s = 37 and 98 nM for human and rat receptors, respectively). It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y6. | | Uses | MRS 2578 has been used an antagonist of purinoceptor P2Y6:
- to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
- in P. aeruginosa infected mice to test its effect on the inflammatory responses
- to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes
| | Uses | MRS 2578 is a selective P2Y66?receptor antagonist. | | Biological Activity | Selective antagonist of P2Y 6 nucleotide receptors; IC 50 values are 37 and 98 nM at human and rat P2Y 6 receptors respectively. Displays no activity at P2Y 1 , P2Y 2 , P2Y 4 and P2Y 11 receptors (IC 50 > 10 μ M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis. | | Biochem/physiol Actions | MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death. | | storage | -20°C (desiccate) | | references | [1] mamedova l k, joshi b v, gao z g, et al. diisothiocyanate derivatives as potent, insurmountable antagonists of p2y6 nucleotide receptors[j]. biochemical pharmacology, 2004, 67(9): 1763-1770. |
| | MRS 2578 Preparation Products And Raw materials |
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