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| | GW441756 Basic information |
| Product Name: | GW441756 | | Synonyms: | 1,3-DIHYDRO-3-[(1-METHYL-1H-INDOL-3-YL)METHYLENE]-2H-PYRROLO[3,2-B]PYRIDIN-2-ONE;GW 441756;Gw;2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-;(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-1H-PYRROLO[3,2-B]PYRIDIN-2-ONE;HYDROCHLORIDE | | CAS: | 504433-23-2 | | MF: | C17H13N3O | | MW: | 275.3 | | EINECS: | | | Product Categories: | Angiogenesis and Metastasis;Inhibitors | | Mol File: | 504433-23-2.mol |  |
| | GW441756 Chemical Properties |
| Boiling point | 568.0±50.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | Soluble in DMSO (up to 5 mg/ml). | | form | solid | | pka | 11.04±0.20(Predicted) | | color | Orange | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | GW441756 Usage And Synthesis |
| Description | GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM). | | Uses | GW 441756 is an effective Trk binder, a novel bioactive molecule used in the treatment of neuroblastoma in infants. | | Definition | ChEBI: 3-[(1-methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one is a member of indoles. | | Biological Activity | Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC 50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases. | | storage | Store at RT | | References | 1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 14 953
2) Takemoto et al. (2015) Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury; Environ. Toxicol. Pharmacol. 40 199 [Focus Citation] |
| | GW441756 Preparation Products And Raw materials |
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