Eperisone hydrochloride

Eperisone hydrochloride Basic information
Product Name:Eperisone hydrochloride
Synonyms:EPERISONE HCL;EPERISONE HYDROCHLORIDE;(4'-ethyl-2-methyl-3-piperidino)propiophenone hydrochloride;1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-1-propanonhydrochloride;4’-ethyl-2-methyl-3-piperidino-propiophenonhydrochloride;e0646;e-646;empp
CAS:56839-43-1
MF:C17H26ClNO
MW:295.85
EINECS:1308068-626-2
Product Categories:Aromatics;Heterocycles;Miscellaneous Biochemicals;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:56839-43-1.mol
Eperisone hydrochloride Structure
Eperisone hydrochloride Chemical Properties
Melting point 169-171°C
storage temp. Inert atmosphere,Room Temperature
solubility Methanol (Slightly), Water (Slightly)
form Solid
color White
CAS DataBase Reference56839-43-1(CAS DataBase Reference)
Safety Information
ToxicityLD50 in male S.D. rats, Wistar rats, mice (mg/kg): 1300, 1850, 1024 orally (Miyagawa)
MSDS Information
Eperisone hydrochloride Usage And Synthesis
DescriptionEperisone hydrochloride is a centrally acting muscle relaxant useful in the management of various spastic conditions including cervical spondylosis and cerebral palsy. It is structurally related to tolperisone.
Chemical PropertiesWhite Solid
OriginatorEisai (Japan)
UsesA spasmolytic agent related structurally to Tolperisone (T535475). Muscle relaxant (skeletal).
UsesUsed as antispasmodic
DefinitionChEBI: Eperisone hydrochloride is an aromatic ketone.
Manufacturing ProcessTo 60 ml of isopropanol, there are introduced 120 g of 4-ethyl-propiophenone, 28.8g of p-formaldehyde and 107 g of piperidine hydrochloride, and the resulting mixture is heated to reflux on an oil bath with stirring. The heating is continued, and when the reaction mixture solidifies, the state being a sign of completion of the reaction, there are added 500 ml of acetone thereinto. The solidified mass is pulverized by crush, recovered by filtration and washed with acetone. 144 g of the crude dry crystalline substance is thus obtained, which is the hydrochloride of the purposed product. The hydrochloride is recrystallized from isopropanol, and there are obtained the crystalline needles having the melting point of 170°C to 172°C.
Brand nameMYONAL
Therapeutic FunctionMuscle relaxant
Eperisone hydrochloride Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Paraformaldehyde-->Piperidine hydrochloride-->4'-Ethylpropiophenone
Triacetonediamine Methylparaben Tolperisone Eperisone hydrochloride Bensulfuron methyl 1-(1-(p-Tolyl)propyl)piperidine hydrochloride 3-dimethylamino-1-(4-methoxyphenyl)propan-1-one hydrochloride Methyl 2-hydroxyethyl cellulose Parathion-methyl Topotecan hydrochloride Sibutramine hydrochloride Tramadol hydrochloride 3-(1-Piperidinyl)propiophenone HCl Tolperisone hydrochloride Thiophanate-methyl 2,2,6,6-Tetramethyl-4-piperidinol Methyl acrylate 3-DIMETHYLAMINO-2-METHYLPROPIOPHENONE HYDROCHLORIDE, 97

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