Escin

Escin Basic information
Product Name:Escin
Synonyms:ESCIN;Chestnuts extract;(2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8R,8aS,9S,10S,12aR,14aR,14bS)-9-Acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid;a-4700;aescusan;amorphousaescin;reparilu;Escin(aescin) Chestnuts
CAS:6805-41-0
MF:C55H86O24
MW:1131.26
EINECS:229-880-6
Product Categories:Inhibitors;Herb extract
Mol File:6805-41-0.mol
Escin Structure
Escin Chemical Properties
Melting point 224.5°C
Boiling point 764.81°C (rough estimate)
density 1.1200 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. 4°C, protect from light
solubility Soluble in methanol.
form powder
color white
Merck 13,3730
Stability:Hygroscopic
CAS DataBase Reference6805-41-0
Safety Information
Hazard Codes Xn
Risk Statements 22-20/22
Safety Statements 22-24/25
RIDADR UN 3077 9 / PGIII
WGK Germany 2
RTECS KF6296000
MSDS Information
ProviderLanguage
SigmaAldrich English
Escin Usage And Synthesis
Chemical Propertiessaponin mixture
OriginatorAescin,Sinochem
Usesmembrane permeabilizer
UsesEscin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, is used and studied as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. It may be used to study its pharmacokinetics, safety and efficacy as a chemosensitizer and modulator of NF-κ B cell signaling.
Usesescin is a saponin occurring in the seed of the horse chestnut tree.
Manufacturing ProcessThe 1st method of preparation of escin (US Patent No. 3,238,190):
500 g of pulverized horse chestnut seeds were extracted two times for 1 hour with 2.5 L each of aqueous 50% methanol with stirring. The solution was filtered, additional methanol was added thereto to increase the methanol concentration to 65%, and then it was filtered again. The obtained solution containing the extracted saponin had a pH of 5 and was passed through a column of 500 ml (wet volume) of cation exchange resin (Lewatit S-100 of Farben-fabriken Bayer A.G.) which had been treated with 65% methanolic 1% sulfuric acid and then had been washed neutral with 65% methanol. The solution leaving the resin had a pH in the range of about 3 to 4 and was concentrated by distillation to about 4/5 of its original volume. On cooling, crystallization of the escin started and the solution was allowed to stand until the crystallization had been completed. Escin having a melting point of 224- 226°C was obtained in a yield of 2%, calculated on the starting material.
The 2st method of preparations of escin (US Patent No. 3,163,636):
An ethereal solution of 1 kg of cholesterol is added to 100 kg of a 10% aqueous-alcoholic horse extract. The resulting emulsion is stirred at 90°C for 1 hour, while the ether is distilled off. The water insoluble saponin-cholesterol precipitate is centrifuged and washed with cold water until the wash water is colorless. The precipitate is air-dried at room temperature. The resulting dustfine powder is extracted with ether in a Soxhlet apparatus for 10 days. The residue is treated with 20 kg of methanol and the undissolved material is filtered off. The yellowish methanol solution is treated with activated charcoal until it is colorless. The methanol is distilled off in a vacuum, and the residue is dried over phosphorus pentoxide in a vacuum not exceeding 1 mm Hg. The yield of pure sodium escinate obtained thereby is about 0.8 kg (8%).


Therapeutic FunctionAntiedemic, Capillary protective
General DescriptionThis substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Flammability and ExplosibilityNonflammable
Escin Preparation Products And Raw materials
Raw materialsMethanol-->Cholesterol
Hecogenin SOY ASAPONIN PANAX NOTOGINSENOSIDES ETHYLENEDIAMINE TETRAKIS(PROPOXYLATE-BLOCK-ETHOXYLATE) TETROL Diphenolic acid alpha-Escin TRIBULOSIDE Escin, hydrogen sulfate, sodium salt beta-Escin, potassium salt Escin sodium ESCIN POLYSULFONATE SODIUM SALT ISATIDS 5-Chlorovaleric acid CHOLESTEROL/ESCIN COMPLEX Ginseng extract Cholest-5-en-3-ol (3beta)-, reaction products with escin sodium salt escin IIa ESCIN, MIXTURE OF SAPONINS OF THE SEED OF AESCULUS HIPPOCASTANUM THE SEED,BETA-ESCIN,B-escin

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.