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| | 5-Bromouridine Basic information |
| | 5-Bromouridine Chemical Properties |
| Melting point | 180-182 °C (dec.) (lit.) | | alpha | -11 º (c=2 in H2O) | | density | 1.9322 (rough estimate) | | refractive index | 1.6520 (estimate) | | storage temp. | -20°C | | solubility | Water (Sonicated) | | pka | 7.73±0.10(Predicted) | | form | Solid | | color | Off-White | | optical activity | [α]22/D 11°, c = 2 in H2O | | Water Solubility | Insoluble in water. | | BRN | 33664 | | CAS DataBase Reference | 957-75-5(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | YU7300000 | | F | 10 | | HS Code | 29349990 |
| | 5-Bromouridine Usage And Synthesis |
| Description | 5-Bromouridine is an energy-related metabolite that is a precursor of uridine. 5-Bromouridine binds to the nuclear DNA in cells, where it can act as a transcriptional regulator. 5-Bromouridine is used in the treatment of malignant brain tumors, where it can inhibit tumor growth by binding to the dna of cancer cells and preventing the synthesis of proteins required for cell division. | | Chemical Properties | WHITE FINE POWDER | | Uses | 5-Bromouridine is often incorporated into RNA in order to detect immunocytochemically and analyzed by cytometry. It possesses anti-viral activity and inhibits the activity of viruses such as human immunodeficiency virus. | | Uses | 5-Bromouridine is a uridine (U829910) derivative and is often incorporated into RNA in order to detect immunocytochemically and analyzed by cytometry. | | Definition | ChEBI: A uridine having a bromo substituent at the 5-position. | | Purification Methods | Recrystallise it from 96% EtOH. UV max 279nm (log 3.95)in 2O pH 1.9. RF in n -BuOH/AcOH/H2O (4:4:1) is 0.49; in n-BuOH/EtOH/H2O (40:11:9) it is 0.46 and in isoPrOH/25%NH3/H2O (7:1:2) it is 0.53 using Whatman No 1 paper. [Pryst.s & Sorm Collect Czech Chem Commmun 29 2956 1964, Beilstein 31 H 24.] |
| | 5-Bromouridine Preparation Products And Raw materials |
| Raw materials | beta-D-Ribofuranose 1,2,3,5-tetraacetate-->2',3',5'-Tri-O-acetyluridine-->5-Bromouracil-->Uridine-->Guanosine | | Preparation Products | (3R)-3,4,5,6-Tetrahydro-4β,5β-dihydroxy-3β,6β-epoxy-2H,8H-pyrimido[6,1-b][1,3]oxazocine-8,10(9H)-dione |
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