Ethyl 2-chloropyrimidine-5-carboxylate

Ethyl 2-chloropyrimidine-5-carboxylate Basic information

Product Name:	Ethyl 2-chloropyrimidine-5-carboxylate
Synonyms:	ETHYL2-CHLOROPYRIMI;Ethyl 2-chloropyrimidine-5-carboxylate ,97%;2-chloro-pyrimidine-5-carboxylic acid ethyl ester;2-Chloro-5-(ethoxycarbonyl)pyrimidine;5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester;ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE;PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester;2-Chloro-5-(ethoxycarbonyl)pyrimidine, 2-Chloro-5-(ethoxycarbonyl)-1,3-diazine
CAS:	89793-12-4
MF:	C7H7ClN2O2
MW:	186.6
EINECS:
Product Categories:	Heterocycle-Pyrimidine series
Mol File:	89793-12-4.mol

Ethyl 2-chloropyrimidine-5-carboxylate Chemical Properties

Melting point	52-60℃
Boiling point	80℃/760mm
density	1.311±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Methanol
form	Solid
pka	-3.05±0.22(Predicted)
color	White to Light yellow
InChI	InChI=1S/C7H7ClN2O2/c1-2-12-6(11)5-3-9-7(8)10-4-5/h3-4H,2H2,1H3
InChIKey	IEMKQRSOAOPKRJ-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(C(OCC)=O)C=N1
CAS DataBase Reference	89793-12-4

Safety Information

MSDS Information

Ethyl 2-chloropyrimidine-5-carboxylate Usage And Synthesis

Chemical Properties	White to light yellow liquid
Uses	Ethyl 2-chloropyrimidine-5-carboxylate is used in the synthesis of Retinoid x receptor agonists (RXR) that are used in the treatment of cancers.

Ethyl 2-chloropyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials	Ethanol-->Hydrochloric acid-->Acetic acid-->Sodium-->N,N-Dimethylformamide-->Toluene-->Phosphorus oxychloride-->Government regulation-->Urea-->Dimethyl sulfate-->N,N-Dimethylaniline-->Ethyl formate-->Ethyl 3-ethoxypropionate-->Ethyl potassium malonate
Preparation Products	5-Pyrimidinecarbonitrile, 2-chloro- (7CI,8CI)-->(2-Pyrrolidin-1-ylpyrimidin-5-yl)methanol

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