Aminopyrine

Aminopyrine Basic information
Product Name:Aminopyrine
Synonyms:2-dihydro-4-(N.,N-dimethylamino-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;4-Dimethylamino-2,3-dimethyl-1-phenyl pyrazol-1-one, 97%;4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Aminopyrine;Amidozon;Aminofebrin;Aminopyrazolin;4-(Dimethylamino)antipyrine, 98+%;4-Dimethylaminoantipyrine,97%
CAS:58-15-1
MF:C13H17N3O
MW:231.29
EINECS:200-365-8
Product Categories:Miscellaneous;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:58-15-1.mol
Aminopyrine Structure
Aminopyrine Chemical Properties
Melting point 107-109 °C(lit.)
Boiling point 373.38°C (rough estimate)
density 1.0744 (rough estimate)
refractive index 1.6140 (estimate)
storage temp. Refrigerator
solubility DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
pkapKa 5.0 (Uncertain)
form Crystalline Powder, Crystals and/or Chunks
color Off-white to brownish
Water Solubility 5.55 g/100 mL
Sensitive Air & Light Sensitive
Merck 14,474
Stability:Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. Degrades under the action of mild oxidizing agents in the presence of moisture or water.
InChIKeyRMMXTBMQSGEXHJ-UHFFFAOYSA-N
CAS DataBase Reference58-15-1(CAS DataBase Reference)
NIST Chemistry ReferenceAminopyrine(58-15-1)
EPA Substance Registry SystemAminopyrine (58-15-1)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38-21/22
Safety Statements 26-36-36/37/39
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS CD2625000
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29331190
Hazardous Substances Data58-15-1(Hazardous Substances Data)
ToxicityLD50 orally in rats: 1.7 g/kg (Hart)
MSDS Information
ProviderLanguage
Aminophenazone English
SigmaAldrich English
ACROS English
ALFA English
Aminopyrine Usage And Synthesis
Chemical PropertiesWhite leaf-like crystals or crystalline powder. Odorless, slightly bitter taste. It is stable in the air, but will deteriorate in sunlight. When there is moisture, it is easy to chemically react with weak oxidants. Soluble in alcohol, chloroform, benzene and ether, soluble in water. The solubility in water increases with the addition of sodium benzoate. Aqueous solutions are weakly alkaline to litmus. The melting point is 107-109°C.
UsesAminopyrine is used as an antipyretic and analgesic drug. It belongs to the pyrazolone derivatives having a most toxic and most dangerous analgesic effect and it is a non-narcotic drug. Due to strong adverse effects, its single medicine preparation is gradually replaced by compound preparation.
ApplicationOxidation by Fe(VI) has potential to remove N-nitrosodiumethylamine precursors, including 4-dimethylaminoantipyrine, from drinking water. 4-Dimethylaminoantipyrine is itself an effective scavenger of reactive nitrogen compounds nitric oxide and peroxynitrite, important in the inflammatory response.
PreparationAminopyrine is synthesized from 4-Aminoantipyrine by catalytic hydrogenation (alkylation). Water is firstly added to the dissolving tank, heated to 50-60°C, put into 4-Aminoantipyrine under stirring, and poured into the hydrogenation tank after complete dissolving. Wash the dissolving tank with water, mix it with the nickel catalyst, and then add it to the hydrogenation tank. The hydrogenation tank was evacuated, then the vacuum valve was closed, hydrogen was introduced, and stirring was started. When the pressure rose to 0.245MPa, the hydrogen was stopped. Add formaldehyde and continue to feed hydrogen. The speed of adding formaldehyde is based on the standard of 1.8-2 cubic meters of hydrogen absorption per 5L of formaldehyde, and the reaction temperature is controlled at 60-85°C. After passing the test, filter by pressure, cool the filtrate to below 25°C, and separate out crystals, which are then filtered to obtain the crude aminopyrine. The crude aminopyrine, ethanol, and activated carbon were heated to 75-80°C, stirred for 1 hour, and filtered under pressure. The filtrate was cooled to 10°C, crystals were precipitated, filtered, washed with ethanol, and air-dried to obtain aminopyrine.
DefinitionChEBI: Aminopyrine is a pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an environmental contaminant and a xenobiotic. It is a tertiary amino compound and a pyrazolone.
Brand nameAdexogan;Agevis;Algimicin anttitermico;Amidazopen;Amidozen;Anoixal;Antigripina;Areumal;Axiston;Balbion;Barsedan;Baukal suppositories;Bayer 1387 p;Bronchisan;Brufaneuseol;Butapyrine;Capsyka dr knapf;Capysal;Chinopyrin;Cibalgin;Ciclazon;Clinit;Coffan;Compral;Cusayth;Demolpas;Dentigoa;Depiral c;Dexa escopyrin;Dha 51;Dialpyrin;Digisab;Dimametten;Dimopyrin;Diprin;Dolo-attirin;Dolo-optineural;Dolorphen;Dolovosano;Donobin;Duerin;Dysmensan;Escopyrinus;Espasnatex;Eufibran;Euprogan;Febren;Febrosolvin;Fenodone;Fever;Flivalgin;Flumil;Framidone;Ftalazon;Funapon;Galenopyrin;Glucopirina;Glucopitina;Helvagit-f;Hemicraneal;Hisense-p;Influnal depot;Inst;Irgapyrine;Isoftal;Kalmine;Katareuma;Lagaflex;Latepyrine;Lauroanginol;Manslu;Medispanmin;Meloka;Neuro-demoplast;Nifedon;Nikartrone;Nostress;Optineural(analgesic);Optipax;Osadrine;Osmotipax;P.s.b.p.;Piracodid;Piradenil;Piradol;Pirasco;Piraseptolo.
World Health Organization (WHO)Aminophenazone, a pyrazolone derivative, has been used as an antiinflammatory and analgesic agent for over a century. Its use has been associated with cases of bone marrow depression and agranulocytosis and more recently it has been claimed to have a carcinogenic potential. Products containing aminophenazone have been formally withdrawn in many countries and marketing has been voluntarily suspended in others. Elsewhere, however, proprietary preparations containing this ingredient may remain available. (Reference: (WHODI) WHO Drug Information, 3, 9, 1977)
General DescriptionSmall colorless crystals or white crystalline powder. Aqueous solution slightly alkaline to litmus. pH (5% water solution) 7.5-9. Odorless. Slightly bitter taste.
Air & Water ReactionsWater soluble.
Reactivity ProfileAminophenazone is sensitive to exposure to light. Aminophenazone is readily attacked by mild oxidizing agents in the presence of water. Aminophenazone is incompatible with acacia, apomorphine, aspirin, chloral hydrate, iodine and tannic acid.
Fire HazardFlash point data for Aminophenazone are not available; however, Aminophenazone is probably combustible.
Biochem/physiol ActionsAntipyrine was found to be nonmutagenic when screened against Salmonella typhimurium tester strains TA100, TA98, TA97, TA102 and TA104.
Safety ProfileHuman poison by unspecified route. Experimental poison by ingestion, subcutaneous, intramuscular,intravenous, and intraperitoneal routes. Moderately toxic by parenteral route. Experimental teratogenic and reproductive effects. Questionable carcinogen when mixed with NaNO2 (1:l). Mutation data reported. Can cause bone marrow depression resulting in leucopenia. Has been implicated in development of aplastic anemia. A tranquilizer. When heated to decomposition it emits toxic fumes of NOx.
MetabolismAminopyrine is very slowly metabolized by normal neonate. In older infants, a higher amount of exhaled 13-CO2 is observed. In chicken aminopyrine-N-demethylase inhibits the activities of some important P-450 enzymes. It is mostly metabolized through N-demethylation to form monomethyl-4-antipyrine and formaldehyde, which can be measured by colorimetry Nash. Aminopyrine Ndemethylase is almost equal to isoform CYP-3A4 and closely linked to the methylation reaction of drugs.
why Aminopyrine Banned?
Purification MethodsIt crystallises from pet ether, sublimes between 80o and 90o, and forms metal complexes. [Beilstein 25 H 452, 25 III/IV 3555.]
Aminopyrine Preparation Products And Raw materials
Raw materialsEthanol-->Formaldehyde-->Dimethyl sulfate-->Sodium metabisulfite-->4-Aminoantipyrine
Chlorodimethylphenylsilane 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Acetaminophen Aminopyrine Glucosamine ETHANE 4-Dimethylaminobenzaldehyde 3-Dimethylaminopropylamine 1,4-DIMETHYLPYRAZOLE 2-Dimethylaminoethanol Dimethyl sulfide Dimethyl fumarate Dimethyl sebacate Dimethyl sulfoxide Dimethyl carbonate N,N-Dimethyl-1,4-phenylenediamine 4-Dimethylaminopyridine Dimethyl sulfate

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