CHOLINE THIEOPHYLLINATE

CHOLINE THIEOPHYLLINATE Basic information
Product Name:CHOLINE THIEOPHYLLINATE
Synonyms:Sabidal SR;CalcliumTheophylineate;theoxylline;Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1);OXTRIPHYLLINE,USP;Sabidal;Teovent;Zy-15061
CAS:4499-40-5
MF:C12H21N5O3
MW:283.33
EINECS:224-798-7
Product Categories:API
Mol File:4499-40-5.mol
CHOLINE THIEOPHYLLINATE Structure
CHOLINE THIEOPHYLLINATE Chemical Properties
Melting point 176-178 °C
storage temp. Store at -20°C
solubility PBS (pH 7.2): 10 mg/ml
form A crystalline solid
Safety Information
HS Code 2939590000
MSDS Information
CHOLINE THIEOPHYLLINATE Usage And Synthesis
OriginatorSabidal ,S.R. Zyma, UK ,1983
UsesOxytrimethylline is used in the treatment for chronic asthma.
UsesBronchodilator.
Manufacturing Process18 parts by weight of theophylline are added to 37.8 parts by weight of aqueous choline bicarbonate (47% assay) and the mixture stirred and heated at 80°C to 90°C until the evolution of carbon dioxide has ceased and complete solution effected. Water is separated from the reaction mixture by distillation under a vacuum sufficient to keep the still temperature between 50°C and 55 C. After about 95 parts by weight of water have been separated, about 80 parts by weight of isopropyl alcohol are added and the mixture subjected to further distillation under a vacuum sufficient to keep the mixture boiling at about 40°C. The distillation removes some of the water as an azeotrope with the isopropyl alcohol. During the removal of the water-isopropyl alcohol azeotrope a crystalline precipitate forms. The mixture is further cooled slowly to 5°C and the crystalline precipitate filtered off. The choline theophyllinate crystals are then washed with isopropyl alcohol and dried under vacuum at about 70°C. A second crop of the product may be obtained from the mother liquor by further reduction in volume and cooling. A yield of 90.5% of theory of choline theophyllinate is obtained completely free of inorganic salts.
Brand nameCholedyl(Parke-Davis).
Therapeutic FunctionSmooth muscle relaxant
CHOLINE THIEOPHYLLINATE Preparation Products And Raw materials
Raw materialsCholine hydroxide-->Theophylline-->Choline bicarbonate
5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol 6-Mercaptopurine Azathioprine CLENBUTEROL Histamine Ketotifen fumarate Pentoxifylline Carmofur Choline chloride Nifedipine Kallikrein Diprophylline Aminophylline 1-(2,6-Dimethylphenoxy)-2-propanamine CHOLINE CHOLINE THIEOPHYLLINATE Choline hydroxide Pamabrom

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