ChemicalBook Product Catalog Organic Chemistry Phosphines 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite Basic information
Product Name:2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
Synonyms:Phosphoramidochloridous acid, bis(1-methylethyl)-, 2-cyanoethyl ester;2-CYANOETHYL DIISOPROPYLCHLOROPHOSPHORAMIDITE, 14.0%-15.7% CL;2-Cyanoethoxy-N,N'-Diisopropyl Chlorophosphoramidate;2-CYANOETHYL N,N-DIISOPROPYLCHLOROPHOSPHORAMIDITE;2-CYANOETHYL DIISDPROPYLCHLOROPHOSPHORAMIDITE;2-CYANOETHYL DIISOPROPYLCHLOROPHOSPHORAMIDITE;CHLORO(DIISOPROPYLAMINO)-BETA-CYANOETHOXYPHOSPHINE;CYANOETHYL N,N-DIISOPROPYL PHOSPHOAMIDOCHLORIDITE
CAS:89992-70-1
MF:C9H18ClN2OP
MW:236.68
EINECS:628-591-6
Product Categories:Phospholipids - 13C & 2H;Phosphorylating and Phosphitylating Agents;SiChem
Mol File:89992-70-1.mol
2-Cyanoethyl N,N-diisopropylchlorophosphoramidite Structure
2-Cyanoethyl N,N-diisopropylchlorophosphoramidite Chemical Properties
Boiling point 103-105°C 0,08mm
density 1.061 g/mL at 25 °C(lit.)
refractive index n20/D 1.479
Fp >230 °F
storage temp. −20°C
solubility Miscible with chloroform and dichloromethane.
pka0.83±0.70(Predicted)
form Crystalline Powder
color clear to very slightly hazy colorless
Sensitive Moisture Sensitive
BRN 3588525
Stability:Hygroscopic, Moisture Sensitive
InChIKeyQWTBDIBOOIAZEF-UHFFFAOYSA-N
CAS DataBase Reference89992-70-1(CAS DataBase Reference)
Safety Information
Hazard Codes C,T
Risk Statements 5-34-29-20/21/22
Safety Statements 26-36/37/39-45-8
RIDADR UN 2845 4.2/PG 1
WGK Germany 3
F 10
HazardClass 8
PackingGroup II
HS Code 29299090
MSDS Information
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2-Cyanoethyl N,N-diisopropylchlorophosphoramidite English
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2-Cyanoethyl N,N-diisopropylchlorophosphoramidite Usage And Synthesis
Chemical PropertiesSlightly Hazy Yellow Liquid
UsesA protecting reagent in DNA synthesis. Also a phosphorylating agent
Uses2-Cyanoethyl diisopropylchlorophosphoramidite is a useful intermediate in organic synthesis. It acts as a protecting reagent in DNA synthesis. It is involved in the selective monophosphorylation of carbohydrates and nucleosides. It plays an essential role in the conversion of protected ribonucleosides to phosphoramidites. It is also utilized as phosphitylating reagent for 3'-hydroxyl groups in the synthesis of oligodeoxyribonucleotides.
2-Cyanoethyl N,N-diisopropylchlorophosphoramidite Preparation Products And Raw materials
(+)-Diisopinocampheyl chloroborane CHLORO(DIMETHYLAMINO)METHOXY-PHOSPHINE 3-Hydroxypropionitrile 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite p-Aminobenzylchloride Chloroacetic acid 2-Chloro-2-methylpropane tert-Butyldimethylsilyl chloride Diisopropylamine hydrochloride Chlorotriethylsilane CHLORO(DIISOPROPYLAMINO)METHOXYPHOSPHINE Difluorochloromethane CHLORO(DIETHYLAMINO)-ETHOXYPHOSPHINE Cinnamyl chloride Polyacrylamide 2-Cyanoethylphosphine Epichlorohydrin 2-Chloropropane
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