1-Bromo-4-(trifluoromethoxy)benzene

1-Bromo-4-(trifluoromethoxy)benzene Basic information
Product Name:1-Bromo-4-(trifluoromethoxy)benzene
Synonyms:4-BROMO-ALPHA,ALPHA,ALPHA-TRIFLUOROANISOLE;4-BROMO(TRIFLUOROMETHOXY)BENZENE;TIMTEC-BB SBB006606;P-TRIFLUOROMETHOXY BROMOBENZENE;Benzene, 1-bromo-4-(trifluoromethoxy)-;1-BROMO-4-(TRIFLUOROMETHOXY)BENZENE;P-Bromotrifluoromethoxybenzen;1-Bromo-4-(Trifluoromethoxy)Be
CAS:407-14-7
MF:C7H4BrF3O
MW:241.01
EINECS:206-979-2
Product Categories:Ethers;Organic Building Blocks;Oxygen Compounds;Fluorobenzene;Aromatic Halides (substituted);Trifluoromethoxybenzene Series;Miscellaneous;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Fluorine Compounds;Building Blocks for Liquid Crystals;Chalcones, etc. (Building Blocks for Liquid Crystals);Functional Materials;Pharmaceutical Intermediate;Trifluoroanisole series;alkyl bromide;bc0001
Mol File:407-14-7.mol
1-Bromo-4-(trifluoromethoxy)benzene Structure
1-Bromo-4-(trifluoromethoxy)benzene Chemical Properties
Boiling point 80 °C50 mm Hg(lit.)
density 1.622 g/mL at 25 °C(lit.)
vapor pressure 20 hPa (55 °C)
refractive index n20/D 1.461(lit.)
Fp 154 °F
storage temp. Sealed in dry,Room Temperature
solubility 11.7mg/l
form Liquid
Specific Gravity1.64
color Clear colorless to yellow
BRN 2046332
InChIInChI=1S/C7H4BrF3O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H
InChIKeySEAOBYFQWJFORM-UHFFFAOYSA-N
SMILESC1(Br)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference407-14-7(CAS DataBase Reference)
NIST Chemistry ReferenceP-bromophenyl trifluoromethyl ether(407-14-7)
Safety Information
Hazard Codes Xn,N,Xi
Risk Statements 22-36/37/38-43-51/53
Safety Statements 26-36/37-61-37/39-36
RIDADR UN 3082 9/PG 3
WGK Germany 1
HazardClass IRRITANT
HS Code 29093090
ToxicityLD50 orally in Rabbit: > 2500 mg/kg
MSDS Information
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1-Bromo-4-(trifluoromethoxy)benzene Usage And Synthesis
Chemical PropertiesCLEAR COLOURLESS TO YELLOW LIQUID
Uses1-Bromo-4-(trifluoromethoxy)benzene was used in the synthesis of 4-{[4-[(2-ethylhexyloxy)-6-(4-morpholinylmethyl)-4-trifluoromethyl][1,1-biphenyl]-3-yl]methyl}morpholine.
Synthesis Reference(s)Journal of the American Chemical Society, 109, p. 3708, 1987 DOI: 10.1021/ja00246a030
General Description1-Bromo-4-(trifluoromethoxy)benzene on treatment with lithium diisopropylamide (LIDA) at -100°C gives 5-bromo-2-(trifluoromethoxy)phenyllithium and at -75°C it eliminates lithium bromide, thus generating 1,2-dehydro-4-(trifluoromethoxy)benzene.
4-(Trifluoromethoxy)aniline (4-Bromo-2-(trifluoromethoxy)phenyl)methanol 2-Amino-1-bromo-4-(trifluoromethoxy)benzene 4-Methoxybenzyl cyanide LABOTEST-BB LT01143471 3,5-Difluoro-4-(trifluoromethoxy)bromobenzene 4-Bromo-2-(trifluoromethoxy)benzene-1-thiol, 95+%,4-BROMO-2-(TRIFLUOROMETHOXY)BENZENE-1-THIOL 4-Bromo-2-(trifluoromethoxy)benzaldehyde RARECHEM AL BD 0523 2-Bromo-5-(trifluoromethoxy)toluene m-Anisyl alcohol 1,3-DIBROMO-5-(TRIFLUOROMETHOXY)BENZENE 2-Bromo-3-(trifluoromethoxy)phenylboronic acid 2-Bromo-5-(trifluoromethoxy)phenylboronic acid 3-BROMO-5-(TRIFLUOROMETHOXY)BENZALDEHYDE 3-NITRO-4-(TRIFLUOROMETHOXY)BROMOBENZENE 3-Amino-4-(trifluoromethoxy)BromoBenzene o-Anisaldehyde

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