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| | Adrenalone Basic information |
| Product Name: | Adrenalone | | Synonyms: | ADRENALONE;AKOS NCG-0050;1-(3,4-dihydroxyphenyl)-2-(methylamino)-ethanon;3,4-dihydroxy-alpha-methylaminoacetophenone;3’,4’-dihydroxy-2-(methylamino)-acetophenon;3’,4’-dihydroxy-2-(methylamino)acetophenone;4-methylaminoacetocatechol;4-methylaminoacetopyrocatechol | | CAS: | 99-45-6 | | MF: | C9H11NO3 | | MW: | 181.19 | | EINECS: | 202-756-9 | | Product Categories: | Pharmaceutical Intermediates | | Mol File: | 99-45-6.mol |  |
| | Adrenalone Chemical Properties |
| Melting point | 235.5°C (rough estimate) | | Boiling point | 314.29°C (rough estimate) | | density | 1.2375 (rough estimate) | | refractive index | 1.5270 (estimate) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Aqueous Acid (Slightly) | | pka | 7.32±0.20(Predicted) | | form | Solid | | color | Pale Yellow to Light Yellow | | Stability: | Hygroscopic |
| | Adrenalone Usage And Synthesis |
| Originator | Adrenalone ,Yick-Vic Chemicals and
Pharmaceuticals (HK) Ltd. | | Uses | Adrenergic (ophthalmic). | | Uses | Adrenalone is a ketone derivative of Epinephrine (E588585) and a potential dopamine β oxidase inhibitor. | | Definition | ChEBI: Adrenalone is an aromatic ketone. | | Preparation | Preparation by reaction of excess 33% aqueous methylamine with 3,4-dihydroxy-a-chloroacetophenone. | | Manufacturing Process | To a suspension of 1 part ω-chloro-3,4-dihydroxyacetophenone (prerared from
chloroacetyl chloride and benzcatechole, see J. Russ. Phys. Chem. Ges., 25,
154) was added dropwise 1 part 60% solution of methylamine. Immediately
was formed a residue of the salt of methylamine and ω-chloro-3,4-
dihydroxyacetophenone. The dissolution of the salt was carried out by heating
of the mixture. Then the salt was converted in crude 3,4-dihydroxy-α-
methylaminoacetophenone. The product was dissolved in dilute hydrochloric
acid. To this solution was added dropwise aqueous ammonium solution to
prepare light yellow crystal of 3,4-dihydroxy-α-methylaminoacetophenone.
The base and the hydrochloride of 3,4-dihydroxy-α-methylaminoacetophenone
decomposed at temperature near 230°C and 240°C respectively. | | Therapeutic Function | Hemostatic, Sympathomimetic, Vasoconstrictor |
| | Adrenalone Preparation Products And Raw materials |
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