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| | Hematoxylin Basic information |
| | Hematoxylin Chemical Properties |
| Melting point | 200 °C (dec.)(lit.) | | Boiling point | 363.32°C (rough estimate) | | density | 1.2514 (rough estimate) | | vapor pressure | 0-0Pa at 20-25℃ | | refractive index | 1.4600 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Soluble in 95% ethanol(1 mg/mL). | | form | Powder/Solid | | Colour Index | 75290 | | pka | 6.7(at 25℃) | | color | Yellow to Brown | | PH Range | Red (0.0) to yellow (1.0);Pale yellow (5.0) to violet (6.0) | | Water Solubility | SOLUBLE IN HOT WATER | | λmax | 292nm, 445nm, 560nm | | Sensitive | Light Sensitive | | Merck | 14,4637 | | BRN | 91399 | | Stability: | Stable, but may discolour on exposure to light. Incompatible with strong oxidizing agents. | | Major Application | Plasma displays, textiles, hair dyes, identifying fresh and stale rice, diag-nosing cancer progression, detecting nosing cancer progression, cervical disease, central nervous system malfunctions, detecting genes, breast cancer, collagen in a tissue sample, apoptosis, demyelinating diseases, antigens, treatment of age-related macular degeneration, burns, prostate cancer, diabetesand obesity, viral diseases, neoplasms, peripheral neural and vascular ailments, skin disorders, biotechnological applications, reference standard materials for cytology, histology andimmunohistochemistry | | InChIKey | WZUVPPKBWHMQCE-UHFFFAOYSA-N | | LogP | 0.3 at 30℃ and pH6.9 | | CAS DataBase Reference | 517-28-2 | | EPA Substance Registry System | Hematoxylin (517-28-2) |
| | Hematoxylin Usage And Synthesis |
| Chemical Properties | light brown crystals or powder | | Uses | Colorant in inks, biological stains. | | Uses | Hematoxylin and eosin together make up Hematoxylin and eosin stain, one of the most commonly used stains in histology. Metal-haematein complexes are used to stain cell nuclei prior to examination under a microscope. Structures that stain with iron- or aluminum-haematein are often called basophilic, even though the mechanism of the staining is different from that of staining with basic dyes. | | Definition | ChEBI: (+)-haematoxylin is a haematoxylin. It is an enantiomer of a (-)-haematoxylin. | | General Description | White to yellowish crystals that redden on exposure to light. | | Air & Water Reactions | Soluble in hot water, slightly water soluble in cold . | | Reactivity Profile | Sensitive to light. . | | Hazard | May be carcinogenic. | | storage | Store at RT | | Purification Methods | Hematoxylin recrystallises from H2O (as trihydrate) in white-yellow crystals which become red on exposure to light and then melt at 100-120o. It has been recrystallised from Me2CO/*C6H6. It has been recrystallised as well from dilute aqueous NaHSO3 until colourless and is soluble in alkali, borax and glycerol. Store it in the dark below 0o. [Morsingh & Robinson Tetrahedron 26 182 1970, Dann & Hofmann Chem Ber 98 1498 1955, Beilstein 17/8 V 469.] |
| | Hematoxylin Preparation Products And Raw materials |
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