2-Benzyloxyethanol

2-Benzyloxyethanol Basic information
Product Name:2-Benzyloxyethanol
Synonyms:2-(benzyloxy)-ethano;2-(phenylmethoxy)-ethano;RARECHEM AL BD 0628;2-Benzyloxyethanol(BzG);Benzyl Cellosolve Benzyl Glycol Ethylene Glycol Monobenzyl Ether;2-Benzyloxyethanol,98%;Ethylene glycol benzyl ether;2-Benzyloxyethanol, 98% 5GR
CAS:622-08-2
MF:C9H12O2
MW:152.19
EINECS:210-719-3
Product Categories:Alcohols;Building Blocks;C9 to C10;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Ethylene Glycols & Monofunctional Ethylene Glycols;Monofunctional Ethylene Glycols
Mol File:622-08-2.mol
2-Benzyloxyethanol Structure
2-Benzyloxyethanol Chemical Properties
Melting point <-75 °C
Boiling point 265 °C (lit.)
density 1.071 g/mL at 25 °C (lit.)
vapor pressure 7.3hPa at 25℃
refractive index n20/D 1.521(lit.)
Fp 110 °C
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka14.40±0.10(Predicted)
form Liquid
Specific Gravity1.07
color Clear colorless
Odormild rose
Water Solubility 4.282g/L(23 ºC)
BRN 2043566
InChIKeyCUZKCNWZBXLAJX-UHFFFAOYSA-N
LogP1.01 at 25℃
CAS DataBase Reference622-08-2(CAS DataBase Reference)
NIST Chemistry ReferenceEthanol, 2-(phenylmethoxy)-(622-08-2)
EPA Substance Registry SystemEthanol, 2-(phenylmethoxy)- (622-08-2)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS KJ7550000
HS Code 29052900
Hazardous Substances Data622-08-2(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Glycol benzyl ether English
SigmaAldrich English
ACROS English
2-Benzyloxyethanol Usage And Synthesis
DescriptionBenzyl-PEG2-alcohol is a PEG linker with an acid labile, benzyl protecting group and a reactive primary alcohol. The primary alcohol can react and further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Chemical PropertiesEthylene glycol monobenzyl ether is a Colorless to light yellow liquid which will dissolve a large number of organic substances among which are oils, fats, greases, some vinyl resins, dewaxed damar, rosin, ester gum, etc. It is used principally as a high boiling solvent in lacquers, inks, and textile dyeing.
Uses2-(Benzyloxy)ethanol has been used in:
  • 9-(2-hydroxyethyl)-linked synthesis of 2,6-diaminopurines
  • synthesis of benzyloxy ethyl methacrylate monomer by esterification with methacryloyl chloride
  • a base-free iridium-catalyzed direct alkylation of active methylene compounds with alcohols
Uses2-Benzyloxyethanol is used in a base-free iridium-catalyzed direct alkylation of active methylene compounds with alcohols.
Synthesis Reference(s)Tetrahedron Letters, 31, p. 389, 1990 DOI: 10.1016/S0040-4039(00)94562-3
HazardToxic by ingestion.
2-Benzyloxyethanol Preparation Products And Raw materials
Preparation ProductsAcetic acid, [2-(phenylmethoxy)ethoxy]--->Vilanterol Impurity 14-->Diethyl azodicarboxylate
2-(trityloxy)ethanol 2-Benzyloxyethanol ETHYLENE Ethanol C8E3 4-Methoxybenzylchloride Reserpine 2-Hydroxyethyl salicylate 4-Methoxyphenylacetone Dibenzoyltartaric acid Ethyleneamines (Trifluoromethoxy)benzene ETHYL 3-PHENYLGLYCIDATE 3-(METHOXYMETHOXY)BENZALDEHYDE p-Anisidine PROPYLENE GLYCOL 2-(3-BROMOPHENYL)-1,3-DIOXOLANE Benzyl

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