ChemicalBook Product Catalog Organic Chemistry Hydrocarbons and derivatives Hydrocarbon nitrification 2-Methoxy-5-nitrophenol

2-Methoxy-5-nitrophenol

2-Methoxy-5-nitrophenol Basic information
Product Name:2-Methoxy-5-nitrophenol
Synonyms:5 nitroguaiacol, 2-methoxy-5-nitrophenol;Phenol, 2-methoxy-5-nitro-;2-Methoxy-5-nitrophenol 98%;2-METHOXY-5-NITROPHENOL / 5-NITROGUAIACOL;2-METHOXY-5-NITROANILINE;2-Methoxy-5-nitrophenol ,99%;2-Methoxy-5-nitrophe;2-Hydroxy-1-methoxy-4-nitrobenzene
CAS:636-93-1
MF:C7H7NO4
MW:169.13
EINECS:211-269-0
Product Categories:Aromatic Phenols;Phenoles and thiophenoles;Building Blocks;C6 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Phenols
Mol File:636-93-1.mol
2-Methoxy-5-nitrophenol Structure
2-Methoxy-5-nitrophenol Chemical Properties
Melting point 103-107 °C (lit.)
Boiling point 110-112 °C/1 mmHg (lit.)
density 1.3375 (estimate)
refractive index 1.5830 (rough estimate)
Fp 110-112°C/1mm
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka8.31±0.19(Predicted)
form Solid
color Light Yellow to Light Brown
BRN 2047074
InChIKeyKXKCTSZYNCDFFG-UHFFFAOYSA-N
CAS DataBase Reference636-93-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 26-36
RIDADR 2811
WGK Germany 3
Hazard Note Irritant
PackingGroup III
HS Code 29095090
MSDS Information
ProviderLanguage
2-Methoxy-5-nitrophenol English
SigmaAldrich English
ALFA English
2-Methoxy-5-nitrophenol Usage And Synthesis
Chemical PropertiesYellow to light brown powder
Uses2-Methoxy-5-nitrophenol is used in the synthesis of potent VEGF and tyrosine kinase inhibitors. Also used in the synthesis of GABA analogues and phosphodiesterase inhibitors such as rolipram.
DefinitionChEBI: 2-Methoxy-5-nitrophenol is a member of 3-nitrophenols.
Synthesis Reference(s)Chemical and Pharmaceutical Bulletin, 28, p. 1287, 1980 DOI: 10.1248/cpb.28.1287
General Description2-Methoxy-5-nitrophenol is the substitution photoproduct formed on irradiation of 2-chloro-4-nitroanisole at 25°C in aqueous NaOH.
2-Methoxy-5-nitrophenol Preparation Products And Raw materials
Preparation Products4,5-DIMETHOXY-2-NITROTOLUENE-->2-Fluoro-4-nitrophenol-->2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE-->4-NITROCATECHOL-->1-METHOXY-4-NITRO-2-(2-PROPYNYLOXY)BENZENE-->3-[2-(dimethylamino)ethoxy]-4-methoxybenzenamine-->SB 216641 HYDROCHLORIDE
Guaifenesin Guaiacol 2-METHOXY-4-NITROPHENOL,o-Methoxy-p-nitrophenol 3-Nitrophenol Nitrophenol Methoxy Sulfogaiacol 2,5-DINITROPHENOL TRITON 2-Amino-4-nitro anisidine 4-Ethyl-2-methoxyphenol 4-Nitrophenol Nitrobenzene 4-Hydroxy-3-methoxystyrene 2-Methoxy-5-nitropyridine 4-tert-Butyl-2-nitrophenol 2-METHOXY-5-NITROPHENOL SODIUM SALT,SODIUM 2-METHOXY-5-NITROPHENOL 2-Methoxy-4-methylphenol
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