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| | Ethoxycarbonyl Isothiocyanate Basic information |
| Product Name: | Ethoxycarbonyl Isothiocyanate | | Synonyms: | Ethyl isothiocyanatidocarbonate;ETHYL ISOTHIOCYANATOFORMATE,98%;(Ethoxyoxomethyl) isothiocyanate;Ethoxy(oxo)methyl isothiocyanate;Isothiocyanatoformic acid ethyl;CARBETHOXYISOTHIOCYANATE;CARBON(ISOTHIOCYANATIDIC)ACID, ETHYL ESTER;ISOTHIOCYANATOFORMIC ACID ETHYL ESTER | | CAS: | 16182-04-0 | | MF: | C4H5NO2S | | MW: | 131.15 | | EINECS: | 240-318-9 | | Product Categories: | Miscellaneous Reagents | | Mol File: | 16182-04-0.mol |  |
| | Ethoxycarbonyl Isothiocyanate Chemical Properties |
| Boiling point | 56 °C18 mm Hg(lit.) | | density | 1.112 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.500(lit.) | | Fp | 123 °F | | storage temp. | 2-8°C | | solubility | Soluble in chloroform and ether. | | form | Oil | | Specific Gravity | 1.112 | | color | Light Yellow | | Sensitive | Moisture Sensitive/Lachrymatory | | BRN | 606091 | | InChIKey | BDTDECDAHYOJRO-UHFFFAOYSA-N | | CAS DataBase Reference | 16182-04-0(CAS DataBase Reference) |
| | Ethoxycarbonyl Isothiocyanate Usage And Synthesis |
| Chemical Properties | Light Yellow Oil | | Uses | Versatile reagent for organic synthesis.
Ethoxycarbonyl isothiocyanate is used as a building block in the synthesis of various heterocycles. It is also used for the synthesis of 1,2,4-oxadiazolidine-3,5-dione. It is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. | | Uses | Ethoxycarbonyl isothiocyanate has been used in the synthesis of:
- pyrazolo[1,5-a][1,3,5]triazine derivatives, potential inhibitors of protein kinase CK2
- fused thiophene derivatives, having antibacterial and antifungal activities
- 4-thiouracil derivatives
- thiocarbamides from stannylarenes
- 1,3,5-triazin-2-one-4-thiones from 2-amino-2-oxazolines
- N-acylthioureas from aminodeoxy sugars
| | Application | Ethoxycarbonyl isothiocyanate reacts with 2-amino-tetrahydrobenzo[b]thiophene derivatives to yield tetrahydrobenzo[b]thiophen-2-thiourea derivatives.
Ethoxycarbonyl isothiocyanate has been used in the synthesis of:
pyrazolo[1,5-a][1,3,5]triazine derivatives, potential inhibitors of protein kinase CK2
fused thiophene derivatives, having antibacterial and antifungal activities
4-thiouracil derivatives
thiocarbamides from stannylarenes
1,3,5-triazin-2-one-4-thiones from 2-amino-2-oxazolines
N-acylthioureas from aminodeoxy sugars | | Synthesis Reference(s) | Using Schiff base as a phase transfer catalyst, ethoxycarbonyl isothiocyanate was synthesized by reacting ethyl chloroformate with sodium thiocyanate. www.semanticscholar.org | | General Description | Ethoxycarbonyl isothiocyanate reacts with 2-amino-tetrahydrobenzo[b]thiophene derivatives to yield tetrahydrobenzo[b]thiophen-2-thiourea derivatives. | | Hazard | Lachrymator. |
| | Ethoxycarbonyl Isothiocyanate Preparation Products And Raw materials |
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