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| | Sodium salicylate Basic information |
| Product Name: | Sodium salicylate | | Synonyms: | Sdium salicylate;Sodium Salicylate 2-Hydroxybenzoic acid monosodium salt Sodium o-hydroxybenzoate;Sodium salicylate BP98;SODIUM SALICYLATE R. G., REAG. PH. EUR.;SODIUM SALICYLATE, REAGENTPLUS TM, >= 99.5%;SODIUM SALICYLATE, PH EUR;SODIUM SALICYLATE, REAGENTPLUS, >=99%;SodiumSalicylatePurified | | CAS: | 54-21-7 | | MF: | C7H5NaO3 | | MW: | 160.1 | | EINECS: | 200-198-0 | | Product Categories: | API;IDOCYL;Pharmaceutical intermediate;54-21-7 | | Mol File: | 54-21-7.mol |  |
| | Sodium salicylate Chemical Properties |
| Melting point | >300 °C (lit.) | | density | 0.32 g/cm3 (20℃) | | storage temp. | Store at +15°C to +25°C. | | solubility | 1000g/l | | form | Crystals or Crystalline Powder | | color | White | | Odor | wh. lustrous cryst. scales or amorphous powd., odorless or faint odor, saline taste | | PH | 6.5 (100g/l, H2O, 20℃) | | Water Solubility | 1000 g/L (20 ºC) | | Sensitive | Light Sensitive | | Merck | 14,8332 | | BRN | 3732792 | | Stability: | Stable. Incompatible with mineral acids, metallic salts, iodine. May be light-sensitive. | | InChIKey | ABBQHOQBGMUPJH-UHFFFAOYSA-M | | LogP | 2.061 (est) | | CAS DataBase Reference | 54-21-7(CAS DataBase Reference) | | EPA Substance Registry System | Sodium salicylate (54-21-7) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-41-36/37/38-36 | | Safety Statements | 26-36 | | WGK Germany | 1 | | RTECS | VO5075000 | | F | 8 | | Autoignition Temperature | >250 °C | | TSCA | Yes | | HS Code | 29182100 | | Toxicity | LD50 i.p. in rats: 780 mg/kg (Goldenthal) |
| | Sodium salicylate Usage And Synthesis |
| Description | Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux. | | Chemical Properties | Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19. | | Chemical Properties | Sodium salicylate, HOC6H4COONa, is a shiny, white powder with sweetish taste and mild aromatic aroma that is soluble in water,glycerol, and alcohol.Used in medicine and as a preservative.
| | Uses | In manufacture of aspirin, methyl salicylate, and other salicylates. Coupling agent for azo dyes. Has been used as food preservative. | | Uses | It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non - steroidal anti - inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultra violet radiation and electrons. | | Uses | keratolytic | | Definition | A salt or
ester of salicylic acid. | | Brand name | Alysine (Marion Merrell Dow). | | General Description | Sodium salicylate may be prepared by the reaction, in aqueoussolution, by adding equal molar ratio of salicylic acidand sodium bicarbonate; evaporating to dryness yields thewhite salt. In solution, particularly in the presence of sodiumbicarbonate, the salt will darken on standing. This is the saltof choice for salicylate medication and usually is administeredwith sodium bicarbonate to lessen gastric distress, or itis administered in enteric coated tablets. However, the useof sodium bicarbonate is ill advised, because it decreases theplasma levels of salicylate and increases the excretion offree salicylate in the urine.
Sodium salicylate, even though not as potent as aspirinfor pain relief, also has less GI irritation and is useful for patientswho are hypersensitive to aspirin. | | Biochem/physiol Actions | Cell permeable: yes | | Safety Profile | Experimental poison by subcutaneous route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by multiple and unspecified routes: toxic psychosis, excitement, respiratory stimulation, nausea or vomiting, and sweating. Experimental reproductive effects. Mutation data reported. A powerful irritant which affects the central nervous system. Incompatible with ferric salts, mineral acids, iodme, lead acetate, silver nitrate, sodium phosphate powder. When heated to decomposition it emits toxic fumes of Na2O. |
| | Sodium salicylate Preparation Products And Raw materials |
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