N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine

N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine Basic information
Product Name:N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
Synonyms:N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-;N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine;N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine;2H-indazol-6aMine,2,3-diMethyl.HCl(1:1);6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole;Pazopanib Impurity 20;BNKY007-PZ01
CAS:444731-74-2
MF:C13H12ClN5
MW:273.72
EINECS:810-051-8
Product Categories:
Mol File:444731-74-2.mol
N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine Structure
N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine Chemical Properties
Melting point >216oC (dec.)
Boiling point 550.0±35.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka2.56±0.30(Predicted)
color Pale Orange to Light Brown
Stability:Hygroscopic
Safety Information
MSDS Information
N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine Usage And Synthesis
UsesN-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine Preparation Products And Raw materials
Raw materials2,3-DIMETHYL-2H-INDAZOL-6-AMINE-->2,3-dimethyl-2H-indazol-6-amine hydrochloride-->2,4-Dichloropyrimidine
Preparation ProductsN-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
4(1H)-Pyrimidinone, 2-chloro- (9CI) N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Pazopanib Related Compound 2 Pazopanib Impurity 9 (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid 1,3-DiMethyl-6-aMino-1H-indazole 2,3-dimethyl-2H-indazol-6-amine hydrochloride 3-Methyl-6-nitro-2H-indazole Pazopanib Related Compound 3 2-Methyl-5-nitrobenzenesulfonamide 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide 3-AMINO-4-METHYLBENZENESULFONAMIDE Pazopanib-d6 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE 1,3-Dimethyl-6-nitro-1H-indazole Pazopanib

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